88146-41-2Relevant articles and documents
A complementary method to obtain N-acyl enamides using the Heck reaction: Extending the substrate scope for asymmetric hydrogenation
Harrison, Paul,Meek, Graham
, p. 9277 - 9280 (2007/10/03)
A series of N-acyl enamides were prepared using the Heck reaction. Asymmetric hydrogenation provided protected amines in up to 99% ee. A method to prepare N-acyl enamides is reported that is complementary to the existing protocols. Heck reaction of a vari
Novel DMARDs on the basis of a new concept of dual cytokine regulation, TNF-α suppression and IL-10 augmentation
Hanano, Tokushi,Adachi, Kunitomo,Aoki, Yoshiyuki,Morimoto, Hiroshi,Naka, Yoichi,Hisadome, Masao,Fukuda, Tetsuko,Sumichika, Hiroshi
, p. 881 - 884 (2007/10/03)
A series of arylpiperazine derivatives was synthesized to obtain agents showing apparent therapeutic effects in a chronic inflammatory animal model, starting from a lead possessing potent dual cytokine regulatory activity in vivo. We found a pyrimidylpipe