88148-56-5Relevant academic research and scientific papers
Synthesis and Reactivity Profile of Ylidenemalononitrile Enamines and Their Ester Analogs Towards Electrophiles and Nucleophiles
Longstreet, Ashley R.,Rivalti, Daniel,McQuade, D. Tyler
, p. 8583 - 8596 (2015/09/15)
Herein, we describe the synthesis and reactivity of enamines derived from ylidenemalononitriles and ylidenecyanoacetates. The enamine scope was expanded by (1) increasing yields of aldehyde-derived ylidenemalononitriles, (2) incorporating silyl functional
Pharmaceutically active compounds and methods of use
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, (2008/06/13)
New fused thiophene compounds are provided and methods of using those compounds for a variety of therapeutic indications. Compounds of the invention are particularly useful for treatment of neuropathic pain.
Indeno[1,2-b]pyrazin-2,3-diones: A new class of antagonists at the glycine site of the NMDA receptor with potent in vivo activity
Jimonet, Patrick,Ribeill, Yves,Bohme, Georg Andrees,Boireau, Alain,Chevé, Michel,Damour, Dominique,Doble, Adam,Genevois-Borella, Arielle,Herman, Frédéric,Imperato, Assunta,Le Guern, Sylvain,Manfré, Franco,Pratt, Jeremy,Randle, John C. R.,Stutzmann, Jean-Marie,Mignani, Serge
, p. 2371 - 2381 (2007/10/03)
Indeno[1,2-b]pyrazin-2,3-diones have been identified as a novel series of potent ligands on the glycine site of the NMDA receptor. To improve their in vivo activities, an acetic acid-type side chain was introduced to the 5- position, giving water-soluble
The Synthesis of Perloline, 6-(3,4-Dimethoxyphenyl)-5-hydroxy-5,6-dihydrobenzonaphthyridin-4(3H)-one
Prager, Rolf H.,Were, Stephen T.
, p. 1441 - 1453 (2007/10/02)
Dehydroperloline is obtained in high overall yield by an intramolecular cyclization of the benzyne generated from 4-(2-bromophenyl)-N-(3,4-dimethoxyphenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (21), by use of lithium hexamethyldisilazide.A benzyne inte
