88150-47-4

Basic information

• Product Name: Amlodipine maleate
• Synonyms: 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester (z)-2-butenedioate;AMLODIPINE MALEATE;AMLODIPINE MALEATE MM STANDARD;AmlodipineMaleateC20H25C1N205.C4H404;3-ethyl 5-Methyl 2-((2-aMinoethoxy)Methyl)-4-(2-chlorophenyl)-6-Methyl-1,4-dihydropyridine-3,5-dicarboxylate Maleate;3-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5;2-[(2-AMINOETHOXY)METHYL)-4-(2-CHLOROPHENYL)-1,4-DIHYDRO-6-METHYL-3,5 PYRIDINEDICARBOXYLIC ACID 3-ETHYL 5-METHYL ESTER B
• CAS NO: 88150-47-4
• Molecular Formula: C₄H₄O₄*C₂₀H₂₅ClN₂O₅
• Molecular Weight: 524.95
• EINECS: 1806241-263-5
• Product Categories: Active Pharmaceutical Ingredients
• Mol File: 88150-47-4.mol
• Article Data: 11

Chemical Properties

• Melting Point: 178-179°
• Boiling Point: 527.2 °C at 760 mmHg
• Flash Point: 272.6 °C
• Appearance: white to pale yellow crystalline powder
• Vapor Pressure: 3.34E-11mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• Stability: Light Sensitive
• CAS DataBase Reference: Amlodipine maleate(CAS DataBase Reference)
• NIST Chemistry Reference: Amlodipine maleate(88150-47-4)
• EPA Substance Registry System: Amlodipine maleate(88150-47-4)

Safety Data

• Hazardous Substances Data: 88150-47-4(Hazardous Substances Data)

Usage

Uses

Anti-anginal; antihypertensive.

Brand name

Amvaz (Dr. Reddy’s).

InChI:InChI=1/C20H25ClN2O5.C4H4O4/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21;5-3(6)1-2-4(7)8/h5-8,17,23H,4,9-11,22H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

Upstream product

• 88150-46-3 2-(2-azidoethoxy)methyl-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine 
• 110-16-7 maleic acid 
• 88150-62-3 4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-2-[2-phthalimidoethoxymethyl]-1,4-dihydropyridine 
• 88150-75-8 ethyl 4-[2-(phthalimido)ethoxy]acetoacetate 
• 88150-42-9 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine 

Downstream Products

• 143290-24-8 2-<<2-<(tert-butoxycarbonyl)amino>ethoxy>-methyl>-4-(2-chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine 

Relevant articles and documents

Synthesis technology of amlodipine maleate

The invention discloses a synthesis technology of amlodipine maleate and relates to the technical field of medicine synthesis, aiming at solving the problem in an existing synthesis technology that more byproducts and impurities exist in industrial production. By controlling parameters of the synthesis technology and reducing the content of the impurities, the purity of the prepared amlodipine maleate reaches 99.5 percent; the self-made amlodipine maleate is used as a raw material for further preparing the amlodipine maleate, so that the cost of a product is reduced and the quality controllability of the product is strong.

PROCESS FOR THE PREPARATION OF AMLODIPINE SALTS

A process for the preparation of salts of amlodipine comprises subjecting a compound of formula (II) to a deprotection reaction and converting the amlodipine free base thus obtained to a salt (1) without isolating amlodipine free base. Preferably, the maleate, besylate, malate or fumarate salt is made.

PROCESS FOR THE PREPARATION OF 1,4-DIHYDROPYRIDINES AND COMPOUNDS USED IN THIS PROCESS

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