88150-47-4Relevant articles and documents
Synthesis technology of amlodipine maleate
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, (2018/09/08)
The invention discloses a synthesis technology of amlodipine maleate and relates to the technical field of medicine synthesis, aiming at solving the problem in an existing synthesis technology that more byproducts and impurities exist in industrial production. By controlling parameters of the synthesis technology and reducing the content of the impurities, the purity of the prepared amlodipine maleate reaches 99.5 percent; the self-made amlodipine maleate is used as a raw material for further preparing the amlodipine maleate, so that the cost of a product is reduced and the quality controllability of the product is strong.
PROCESS FOR THE PREPARATION OF AMLODIPINE SALTS
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Page/Page column 11-12, (2008/06/13)
A process for the preparation of salts of amlodipine comprises subjecting a compound of formula (II) to a deprotection reaction and converting the amlodipine free base thus obtained to a salt (1) without isolating amlodipine free base. Preferably, the maleate, besylate, malate or fumarate salt is made.
PROCESS FOR THE PREPARATION OF 1,4-DIHYDROPYRIDINES AND COMPOUNDS USED IN THIS PROCESS
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Page 11-12, (2010/02/08)
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