881653-57-2

Upstream product

• 121025-48-7 C₁₉H₂₅NOSi 
• 95-55-6 2-amino-phenol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 69589-21-5 O-tert-butyldimethylsilyl-2-aminophenol 
• 18052-27-2 tert-butyldimethyl(phenoxy)silane 
• 100-46-9 benzylamine 
• 1624-53-9 2-(benzylideneamino)phenol 
• 46425-95-0 o-(benzylamino)phenol 

Downstream Products

• 881653-84-5 4-tert-butyl-cyclohex-1-enecarboxylic acid benzyl-[2-(tert-butyl-dimethyl-silanyloxy)-phenyl]-amide 
• 1450761-14-4 2-(allyl(benzyl)amino)phenol 
• 881653-65-2 trifluoro-methanesulfonic acid 2-{benzyl-[4-(benzyl-phenyl-carbamoyl)-7-oxa-bicyclo[4.1.0]hept-3-ene-3-carbonyl]-amino}-phenyl ester 
• 881653-63-0 trifluoro-methanesulfonic acid 2-{benzyl-[2-(benzyl-phenyl-carbamoyl)-cyclohexa-1,4-dienecarbonyl]-amino}-phenyl ester 
• 881653-61-8 cyclohexa-1,4-diene-1,2-dicarboxylic acid 1-{benzyl-[2-(tert-butyl-dimethyl-silanyloxy)-phenyl]-amide} 2-(benzyl-phenyl-amide) 
• 881653-77-6 trifluoro-methanesulfonic acid 2-[benzyl-(2-dimethylcarbamoyl-cyclohexa-1,4-dienecarbonyl)-amino]-phenyl ester 
• 881653-75-4 cyclohexa-1,4-diene-1,2-dicarboxylic acid 1-{benzyl-[2-(tert-butyl-dimethyl-silanyloxy)-phenyl]-amide} 2-dimethylamide 
• 881653-86-7 trifluoro-methanesulfonic acid 2-[benzyl-(4-tert-butyl-cyclohex-1-enecarbonyl)-amino]-phenyl ester 

Relevant academic research and scientific papers

Direct Aryl C?H Amination with Primary Amines Using Organic Photoredox Catalysis

The direct catalytic C?H amination of arenes is a powerful synthetic strategy with useful applications in pharmaceuticals, agrochemicals, and materials chemistry. Despite the advances in catalytic C?H functionalization, the use of aliphatic amine coupling partners is limited. Described herein is the construction of C?N bonds, using primary amines, by direct C?H functionalization with an acridinium photoredox catalyst under an aerobic atmosphere. A wide variety of primary amines, including amino acids and more complex amines are competent coupling partners. Various electron-rich aromatics and heteroaromatics are useful scaffolds in this reaction, as are complex, biologically active arenes. We also describe the ability to functionalize arenes that are not oxidized by an acridinium catalyst, such as benzene and toluene, thus supporting a reactive amine cation radical intermediate.

Enantioselective synthesis of benzofurans and benzoxazines via an olefin cross-metathesis-intramolecular oxo-Michael reaction

Chiral phosphoric acid and Hoveyda-Grubbs II were found to catalyze an olefin cross-metathesis-intramolecular oxo-Michael cascade reaction of the ortho-allylphenols and enones to provide a variety of benzofuran and benzoxazine derivatives in moderate to good yields and enantioselectivity.

Diastereoselection in the formation of spirocyclic oxindoles by the intramolecular heck reaction

Diastereoselective double Heck cyclizations of cyclohexene diamides 1 and 3 form contiguous quaternary stereocenters, with diastereoselection being controlled by the trans-diol protecting group. In this, the first in a series of two papers, the origin of