881667-64-7

Upstream product

• 881667-67-0 6-[(2S,4S)-6-Benzyloxy-2-hydroxy-4-(4-methoxy-benzyloxy)-hexyl]-2,2-dimethyl-[1,3]dioxin-4-one 
• 881667-61-4 6-[(2S,4S)-6-Benzyloxy-2-benzyloxymethoxy-4-(4-methoxy-benzyloxy)-hexyl]-2,2-dimethyl-[1,3]dioxin-4-one 
• 881667-62-5 6-[(2S,4S)-6-Benzyloxy-2-benzyloxymethoxy-4-(4-methoxy-benzyloxy)-hexyl]-2-butoxy-2,3-dihydro-pyran-4-one 
• 3587-60-8 Benzyloxymethyl chloride 

Downstream Products

• 881667-65-8 (6R,8S,10S)-8-(2-Benzyloxy-ethyl)-10-benzyloxymethoxy-1,7-dioxa-spiro[5.5]undec-2-en-4-one 
• 881667-68-1 (2R,4S,6R,8S,10S)-8-(2-Benzyloxy-ethyl)-10-benzyloxymethoxy-4-methyl-2-vinyl-1,7-dioxa-spiro[5.5]undecan-4-ol 
• 215160-87-5 (2R,4S,6R,8S,10S)-8-(2-Benzyloxy-ethyl)-4-methyl-2-vinyl-1,7-dioxa-spiro[5.5]undecane-4,10-diol 

Relevant academic research and scientific papers

A hetero-Diels-Alder approach to complex pyrones: An improved synthesis of the spongistatin AB spiroketal

The conversion of a substituted dioxinone to a pyrone was used in an improved synthesis of the AB spiroketal subunit of the spongistatins. This transformation occurred via a hetero-Diels-Alder reaction of an acyl ketene with butyl vinyl ether. A double diastereoselective Mukaiyama aldol reaction is used to provide the hetero-Diels-Alder precursor.