881667-67-0Relevant articles and documents
A hetero-Diels-Alder approach to complex pyrones: An improved synthesis of the spongistatin AB spiroketal
Crimmins, Michael T.,Smith, Aaron C.
, p. 1003 - 1006 (2006)
The conversion of a substituted dioxinone to a pyrone was used in an improved synthesis of the AB spiroketal subunit of the spongistatins. This transformation occurred via a hetero-Diels-Alder reaction of an acyl ketene with butyl vinyl ether. A double diastereoselective Mukaiyama aldol reaction is used to provide the hetero-Diels-Alder precursor.