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General Description

2-Amino-5-(2-bromoacetyl)benzonitrile is a chemical compound with the molecular formula C9H8BrN3O. It is a derivative of benzonitrile, containing an amino group and a bromoacetyl group attached to the benzene ring. 2-aMino-5-(2-broMoacetyl)benzonitrile is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It has also been studied for its potential anticancer and antimicrobial properties. Additionally, the bromoacetyl group makes it a useful reagent for the modification of other organic compounds. The compound's structure and properties make it valuable in various chemical and biological applications.

Upstream product

• 56759-32-1 1-(4-amino-3-bromophenyl)-ethanone 
• 33720-71-7 4-amino-3-cyanoacetophenone 
• 99-92-3 p-aminobenzophenone 

Downstream Products

• 1246819-04-4 D₉-cimbuterol 
• 54239-37-1 cimaterol 
• 54239-39-3 5-[2-(tert-butylamino)-1-hydroxyethyl]anthranilonitrile 

Relevant academic research and scientific papers

4-AMINOBUT-2-ENAMIDE DERIVATIVES AND SALTS THEREOF

The present invention provides an antitumor agent comprising a compound or a pharmaceutically acceptable salt thereof that covalently binds to GTP-bound KRASG12C as an active ingredient.

Phenylethanolamine β receptor agonist synthetic method

The invention discloses a phenylethanolamine β receptor agonist synthetic method, comprises the following steps: S1: the 4 - amino acetophenone dissolved in an organic solvent, with the electrophilic reagent occurs on the benzene ring substituted halogenated reaction, generating [...] intermediate; [...] intermediates in organic solvent or in water, under the catalysis of the metal catalyst with the cyanide reagent undergo nucleophilic substitution reaction, generating phenyl ketone intermediate; S2: phenyl ketone intermediates in organic solvent, with the copper bromide generating carbonyl α bromo reaction to produce α - bromoacetophenone intermediates; S3: α - bromoacetophenone intermediates in organic solvent with tert-butyl amine or isopropylamine reaction intermediates acetophenone amines; S4: acetophenone amine intermediates in organic solvent, with the reduction hydrogenation reagent react to generate the phenylethanolamine β receptor agonists; synthetic method of this invention a simple and highly efficient and cheap and easy to obtain, atom utilization is high, the synthetic product chemical purity is greater than 99%, to meet the detection requirements of the food safety.

Synthesis of stable isotope labeled D9-Mabuterol, D9-Bambuterol, and D9-Cimbuterol

Three stable and simple synthetic routes of labeled D9-Mabuterol, D9-Bambuterol, and D9-Cimbuterol were described with 98.5%, 99.7%, and 98.4% isotopic abundance and good purity. These structures and isotope-abundance were confirmed according to 1H NMR and liquid chromatography-tandem mass spectrometry.

Efficient synthesis of D6-clenproperol and D6-cimaterol using deuterium isopropylamine as labelled precursor

This report presents an efficient synthesis of D6-clenproperol and D6-cimaterol with 99.5% and 99.7% isotopic abundance in acceptable yields and excellent chemical purities with deuterium isopropylamine as labelled precursor. Their structures and the isotope-abundance were confirmed by proton nuclear magnetic resonance and liquid chromatography–mass spectrometry.

NOVEL PHENYLETHANOLAMINE COMPOUNDS HAVING BETA2-ACCEPTOR EXCITATORY FUNCTION AND THEIR PREPARATION METHOD

The invention provides compounds of formula ( I ) and pharmaceutically acceptable salts thereof, wherein R1 is H, chlorine, or bromine; R2 is electron attractive groups selected from the group consisting of CF3, CN, fluori

Heteroarylethanol-pyridylalkylamines for controlling animal growth

A compound for promoting livestock production and for controlling obesity in humans and animals, of the formula STR1 in which A represents =CH-- or =N--, R0 represents hydrogen or methyl, R1 and R3 each independently represents hydrogen, hydroxyl, halogen, cyano, alkyl, halogenoalkyl, hydroxyalkyl, alkoxycarbonyl, aminocarbonyl, mono- and dialkylaminocarbonyl, alkoxy, halogenoalkoxy, halogenoalkylthio, NHSO2 -alkyl, R2 represents hydrogen, hydroxyl, alkoxy or the radical --NR5 R6, R4 represents hydrogen, C1 -C10 -alkyl which is optionally substituted by hydroxyl, halogen, alkoxy, acyloxy or the radical --NH7 R8, or represents the radical COR9 or the radical --O--Z--R10, Z represents C1 -C10 -alkylene, -alkenylene or alkynylene, R5 represents hydrogen or alkyl, R6 represents hydrogen, alkyl, halogenoalkyl or acyl, or R5 and R6 together with the adjoining N atom form a saturated or unsaturated heterocyclic 4-, 5- or 6-membered ring, R7 and R8 each independently represents hydrogen, optionally substituted alkyl, optionally substituted aryl, R9 represents hydroxyl, alkoxy or the radical --NR7 R8, R10 represents hydroxyl, alkoxy, acyloxy, optionally substituted aryloxy or aralkyloxy, with the substituent R4 and the alkylamino group in the pyridyl ring of the formula I being in the p position with respect to one another, or a physiologically tolerated salt thereof, or, if A represents nitrogen, optionally the N-oxide thereof.

Novel arylethanolamines for promoting livestock production

The growth of livestock is promoted by the novel arylethanolamines of the formula STR1 in which R1 represents cyano, R2 represents amino, alkylamino or acylamino, R3 represents hydrogen, halogen, alkyl, halogenoalkyl, alkoxy, halogenoalkoxy, hydroxymethyl, nitro or methylsulphonylmethyl, R4 represents hydrogen, alkyl or acyl, R5 represents hydrogen or alkyl, R6 represents alkyl, n represents 1, 2 or 3, R7 represents the radicals --COR9, --O-alkylene-COR9, -alkylene-R10 or --O-alkylene-R10, R8 represents hydrogen, alkyl or halogen, R9 represents hydroxyl, alkoxy or the radical --NR11 R12, R10 represents hydroxyl, alkoxy or the radical NR11 R12, R11 represents hydrogen or alkyl, and R12 represents hydrogen or alkyl, and the physiologically acceptable salts thereof.

Repartitioning Agents: 5--anthranilonitrile and Related Phenethanolamines; Agents for Promoting Growth, Increasing Muscle Accretion and Reducing Fat Deposition in Meat-producing Animals

A series of phenethanolamines related to clenbuterol was prepared and examined in mice for growth-promoting and fat-reducing activities.Several analogs were equipotent to clenbuterol.In chickens, 5-anthranilonitrile appeared to be more potent than clenbuterol with recpect to "repartitioning" activity, that is, the ability to redirect food energy from fat formation to muscle accretion.Based on this potency and low residue levels in edible tissues, this compound is in advanced stages of evaluation for commercial use in meat animals.