881672-72-6Relevant articles and documents
Identification and synthesis of novel inhibitors of acetyl-CoA carboxylase with in vitro and in vivo efficacy on fat oxidation
Keil, Stefanie,Müller, Marco,Zoller, Gerhard,Haschke, Guido,Schroeter, Katrin,Glien, Maike,Ruf, Sven,Focken, Ingo,Herling, Andreas W.,Schmoll, Dieter
supporting information; experimental part, p. 8679 - 8687 (2011/03/19)
Acetyl CoA carboxylase isoforms 1 and 2 (ACC1/2) are key enzymes of fat utilization and their inhibition is considered to improve aspects of the metabolic syndrome. To identify pharmacological inhibitors of ACC1/2, a high throughput screen was performed w
