881672-72-6Relevant academic research and scientific papers
Identification and synthesis of novel inhibitors of acetyl-CoA carboxylase with in vitro and in vivo efficacy on fat oxidation
Keil, Stefanie,Müller, Marco,Zoller, Gerhard,Haschke, Guido,Schroeter, Katrin,Glien, Maike,Ruf, Sven,Focken, Ingo,Herling, Andreas W.,Schmoll, Dieter
supporting information; experimental part, p. 8679 - 8687 (2011/03/19)
Acetyl CoA carboxylase isoforms 1 and 2 (ACC1/2) are key enzymes of fat utilization and their inhibition is considered to improve aspects of the metabolic syndrome. To identify pharmacological inhibitors of ACC1/2, a high throughput screen was performed w
2-Benzyl and 2-phenyl-3-hydroxypropyl pivalates as protein kinase C ligands
Lee, Jeewoo,Lee, Ju-Hyun,Kim, Su Yeon,Perry, Nicholas A.,Lewin, Nancy E.,Ayres, Jolene A.,Blumberg, Peter M.
, p. 2022 - 2031 (2007/10/03)
A series of 2-benzyl and 2-phenyl-3-hydroxypropyl pivalates designed to incorporate the principal pharmacophores of phorbol esters have been synthesized and tested as PKC-α ligands. Among the analogues, 13c exhibited the most potent binding affinity with a Ki = 0.7 μM. The synthesized analogues were subjected to molecular modeling analysis based on two alternative models of the phorbol pharmacophore and a docking study of 13c was carried out.
