88174-53-2

Upstream product

• 15764-16-6 2,4-dimethylbenzaldehyde 
• 4885-02-3 Dichloromethyl methyl ether 
• 556-96-7 5-bromo-1,3-xylene 

Downstream Products

• 128651-76-3 2-Acetylamino-N-(2-bromo-4,6-dimethylbenzylidene)ethylamine 
• 128651-79-6 2-Acetylamino-N-(2-bromo-4,6-dimethylbenzylidene)cyclohexylamine 
• 128651-81-0 2-Acetylamino-N-(2-cyano-4,6-dimethylbenzylidene)ethylamine 
• 128651-83-2 2-Acetylamino-N-(2-cyano-4,6-dimethylbenzylidene)cyclohexylamine 

Relevant academic research and scientific papers

Silver/Rhodium Relay Catalysis Enables C?H Functionalization of In Situ Generated Isoquinolines with Sulfoxonium Ylides: Construction of Hexahydrodibenzo[a,g]quinolizine Scaffolds

Employing silver/rhodium relay catalysis strategy, an intramolecular electrophilic cyclization and C?H activation followed by cascade hydrogenation and reductive amination has been developed. The acylmethylated isoquinoline derivatives could be afforded with broad substrate scope in 23–88% yields, which could be further transformed to the core skeleton of hexahydrodibenzo[a,g]quinolizine as drug-candidates. Moreover, this reaction was achieved in a gram-scale. A reasonable reaction mechanism has been proposed based on a series of control and KIE experiments. (Figure presented.).

Palladium-catalyzed ortho-C(sp2)[sbnd]H bromination of benzaldehydes via a monodentate transient directing group strategy

A facile and efficient monodentate transient directing group strategy was developed to enable the palladium-catalyzed ortho-C(sp2)[sbnd]H bromination of benzaldehydes. A broad scope of benzaldehydes were transformed into the desired products by employing 2-amino-5-chlorobenzotrifluoride as a monodentate transient directing group, demonstrating good functional group tolerance. Mild reaction conditions and no requirement for a silver salt are also features of this strategy.

A direct and mild formylation method for substituted benzenes utilizing dichloromethyl methyl ether-silver trifluoromethanesulfonate

A silver trifluoromethanesulfonate (AgOTf)-promoted direct and mild formylation of benzenes has been developed. The reaction utilizing dichloromethyl methyl ether (Cl2CHOMe) and AgOTf powerfully formylated various substituted benzenes under temperature conditions as low as -78 C without losing the protecting groups on the phenolic hydroxyl group.