881748-07-8

Upstream product

• 848033-62-5 (2S,4aS,7R,8aR)-N-benzyl-2-(N-methyl-N-methoxyaminocarbonyl)-4,4,7-trimethyloctahydrobenzo[e][1,3]oxazine 
• 109-72-8 n-butyllithium 

Downstream Products

• 881748-24-9 (2S,2S',4a'S,7'R,8a'R)-2-(3-benzyl-4',4',7'-trimethyloctahydro-2H-benzo[e][1,3]oxazin-2'-yl)-1,1,1-trifluorohexan-2-ol 
• 881748-39-6 (2S)-N-benzyl-N-(2-trifluoromethyl-2-hydroxyhexan-1-yl)-8'-aminomenthol 

Relevant academic research and scientific papers

An efficient synthesis of enantiomerically enriched trifluoromethylated 1,2-diols and 1,2-amino alcohols with quaternary stereocenters by diastereoselective addition of TMSCF3 to chiral 2-acyl-1,3- perhydrobenzoxazines

TMSCF3 adds to chiral 2-acyl-1,3-perhydrobenzoxazines with total diastereoselectivity leading to quaternary trifluoromethyl alcohols. Further transformation of the addition products yields enantiomerically enriched trifluoromethylated 1,2-diols