88183-84-0

Upstream product

• 84207-68-1 N⁶,6'-dibenzoylneplanocin A 
• 98-88-4 benzoyl chloride 
• 72877-50-0 neplanocin A 
• 88183-83-9 N⁶,6'-dibenzoylneplanocin A 2',3'-O-cyclic thiocarbonate 
• 79386-50-8 (3'R,4'S,5'R)-3'-(6-aminopurin-9-yl)-1'-hydroxymethyl-4',5'-O-isopropylidene-cyclopent-1'-en-4',5'-diol 

Relevant academic research and scientific papers

Nucleosides and Nucleotides. XXXXV. Facile Deoxygenation of Neplanocin A and Nucleosides by the Use of Tri-n-butyltin Hydride

2'(R)-Halogeno-2'-deoxyneplanocin A's were hydrogenated with tri-n-butyltin hydride to yield 2'-deoxyneplanocin A.The same compound was obtained by reduction ot the 2'-O-(1-imidazolyl)thiocarbonyl derivative of neplanocin A.This procedure was also applicable to the synthesis of 2'-deoxyadenosine and -guanosine from the corresponding ribosides.Treatment of a neplanocin 2',3'-O-cyclic thiocarbonate with tri-n-butyltin hydride gave 3'-deoxyneplanocin selectively in high yield.Keywords --- neplanocin A; nucleoside antibiotic; 2'-deoxyneplanocin A; 3'-deoxyneplanocin A; tri-n-butyltin hydride; radical reduction; 2'-deoxyribonucleosides; NMR; 2'-deoxyadenosine; 2'-deoxyguanosine