881845-68-7Relevant academic research and scientific papers
A solid-phase total synthesis of the cyclic depsipeptide HDAC inhibitor spiruchostatin A
Iijima, Yusuke,Munakata, Asami,Shin-ya, Kazuo,Ganesan,Doi, Takayuki,Takahashi, Takashi
, p. 2970 - 2972 (2009)
Spiruchostatin A, a potent histone deacetylase inhibitor, was efficiently synthesized from (3S,4R)-4-amino-3-hydroxy-5-methylhexanoic acid utilizing solid-phase peptide elongation with d-cysteine, d-alanine, and (E)-3-hydroxy-7-thio-4-heptenoic acid and s
A total synthesis of spiruchostatin A
Doi, Takayuki,Iijima, Yusuke,Shin-Ya, Kazuo,Ganesan,Takahashi, Takashi
, p. 1177 - 1180 (2007/10/03)
We achieved the total synthesis of the histone deacetylase inhibitor spiruchostatin A, as the prelude to the preparation of a combinatorial library of its analogues. Two key reactions were an asymmetric acetate aldol reaction using a Zr-enolate and macrol
