881854-96-2

Basic information

• Product Name: 4-(2-chloro-4-fluorobenzyloxy)-3,5-dimethoxybenzaldehyde
• CAS NO: 881854-96-2
• Molecular Weight: 324.736
• Mol File: 881854-96-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(2-chloro-4-fluorobenzyloxy)-3,5-dimethoxybenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-chloro-4-fluorobenzyloxy)-3,5-dimethoxybenzaldehyde(881854-96-2)
• EPA Substance Registry System: 4-(2-chloro-4-fluorobenzyloxy)-3,5-dimethoxybenzaldehyde(881854-96-2)

Safety Data

• Hazardous Substances Data: 881854-96-2(Hazardous Substances Data)

Upstream product

• 134-96-3 syringic aldehyde 
• 208186-84-9 (2-chloro-4-fluorophenyl)methanol 
• 3840-31-1 (3,4,5-trimethoxyphenyl)methanol 
• 1916-07-0 3,4,5-trimethoxybenzoic acid methyl ester 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 

Downstream Products

• 881855-04-5 4-O-(2-chloro-4-fluorobenzyl)sinapic acid ethyl ester 

Relevant articles and documents

Design, synthesis, and SAR analysis of cytotoxic sinapyl alcohol derivatives

Five series totalling 51 of sinapyl alcohol derivatives were designed and synthesized. Their cytotoxicity analyses were performed on six human tumor cell lines such as PC-3, CNE, KB, A549, BEL-7404, and HeLa. Certain sinapyl alcohol derivatives showed significant cytotoxic activities. Compound 14d exhibited especially potent cytotoxicity against the BEL-7404 cell line with an IC 50 value of 0.7 μM, which showed more cytotoxic activity than the positive control, cisplatin. The structure-cytotoxicity relationships were discussed and the CoMFA analysis was performed using the cytotoxic data against HeLa cells as a template.