208186-84-9

Usage

Chemical Properties

WHITE CRYSTALLINE POWDER

InChI:InChI=1/C7H6ClFO/c8-7-3-6(9)2-1-5(7)4-10/h1-3,10H,4H2

Upstream product

• 84194-36-5 2-chloro-4-fluorobenzaldehyde 
• 2252-51-9 2-choro-4-fluorobenzoic acid 
• 85953-29-3 methyl 2-chloro-4-fluorobenzoate 

Downstream Products

• 881854-96-2 4-(2-chloro-4-fluorobenzyloxy)-3,5-dimethoxybenzaldehyde 
• 525570-29-0 4-(2-chloro-4-fluoro-benzyloxy)-3-methoxy-benzaldehyde 
• 219765-26-1 2-chloro-4-fluorobenzyl mesylate 
• 1013915-60-0 sodium 2-chloro-4-fluorobenzyloxymethyl trifluoroborate 
• 1258458-51-3 [2-(3-acetyl-pyrazol-1-ylmethyl)-oxazol-4-yl]-carbamic acid 2-chloro-4-fluoro-benzyl ester 
• 1393724-19-0 (R)-3-(3-(4-(2-chloro-4-fluorobenzyloxy)phenyl)-2-((4,5-dimethoxy-2-nitrobenzyloxy)carbonylamino)propanamido)propanoic acid 
• 84194-36-5 2-chloro-4-fluorobenzaldehyde 
• 69943-47-1 (2-chloro-4-fluorophenyl)(phenyl)methanone 
• 1620217-67-5 1-benzyl-2-chloro-4-fluorobenzene 

Relevant academic research and scientific papers

N-(Substituted sulfonyl)benzamide derivative and preparation method and pharmaceutical application thereof

The invention relates to an N-(substituted sulfonyl)benzamide derivative and preparation method and pharmaceutical application thereof, in particular to an N-(substituted sulfonyl)benzamide derivativeshown as general formula (I), preparation method thereof, medicinal salts of the derivative, and their application as therapeutics, especially as Nav1.7 inhibitors, wherein substituents in the general formula (I) shown in the description are defined the same as in the description.

Zinc-Mediated Efficient and Selective Reduction of Carbonyl Compounds

We herein describe for the first time that an optimized combination of Zn and NH4Cl can be used for the selective reduction of aldehydes and ketones to the corresponding alcohols. The aldehyde and keto groups are selectively reduced in the presence of azide, cyano, epoxy, ester, and carbon–carbon double-bond functional groups. A broad functional-group compatibility, chemoselective reduction of aldehydes in the presence of ketones, and selective reduction of isatins at the C3 carbonyl group are the highlights of the present method.

Synthesis of structurally diverse diarylketones through the diarylmethyl sp3 C-H oxidation

Under open-flask conditions, an efficient method to assemble a series of diversely functionalized diarylketones in the presence of commercially available NBS has been developed. Yields of up to 99% have been achieved employing diarylmethanes as starting material. Based on 18O-labeled experiment, the addition of stoichiometric water eventually leads to excellent yields in all carbonylation cases.

A simple reduction of methyl aromatic esters to alcohols using sodium borohydride-methanol system

Several aromatic esters were reduced to the corresponding alcohol by using sodium borohydride-methanol system. The reduction was completed within 2.0-4.0h after refluxing in THF. The alcohol products were isolated after aqueous workup in good yields (88-97%).

Sulfonamide compounds and medicinal use thereof

A sulfonamide compound of the formula (I):R 1 --SO 2 NHCO--A--R 2 (I)wherein R 1 is alkyl, alkenyl, alkynyl and the like; A is an optionally substituted heteropolycyclic group except benzimidazolyl, indolyl, 4,7-dihydrobenzimidazolyl and 2,3-dihydrobenzoxazinyl; X is alkylene, oxa, oxa(lower)alkylene and the like; and R 2 is optionally substituted aryl, substituted biphenylyl and the like, a salt thereof and a pharmaceutical composition comprising the same. The sulfonamide compound is effective for the diseases treatable based on their blood sugar level-depressing activity, cGMP-PDE (especially PDE-V)-inhibiting activity, smooth muscle relaxing activity, bronchodilating activity, vasodilating activity, smooth muscle cell suppressing activity, and antiallergic activity.