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Usage

Uses

Used in Pharmaceutical Industry:
ExeMestane Related Compound is used as an aromatase inhibitor for the treatment of hormone-dependent breast cancer. It works by reducing the levels of estrogen in the body, thereby inhibiting the growth of cancer cells.
Used in Cancer Research:
ExeMestane Related Compound is used as a research tool for studying the mechanisms of aromatase inhibition and its effects on hormone-dependent cancers. This helps in the development of new drugs and therapies for the treatment of various types of cancer.
Used in Drug Synthesis:
ExeMestane Related Compound is used as an intermediate in the synthesis of Exemestane, a widely used drug for the treatment of hormone-dependent breast cancer. Its presence in the synthesis process highlights its importance in the development of effective cancer treatments.

Upstream product

• 67-56-1 methanol 
• 121021-51-0 6β-hydroxymethylandrosta-1,4-diene-3,17-dione 
• 67737-88-6 1α,3-dipyrrolidinylandrosta-3,5-dien-17-one 
• 933455-74-4 6α-hydroxymethylandrosta-1,4-diene-3,17-dione 
• 74-88-4 methyl iodide 
• 897-06-3 Androsta-1,4-diene-3,17-dione 

Relevant academic research and scientific papers

6-SUBSTITUTED ESTRADIOL DERIVATIVES FOR USE IN REMYELINATION OF NERVE AXONS

Disclosed is a method of remyelinating axons with 6-substituted estradiol compounds of the formula The methods can be used to treat a variety of demyelinating diseases.

(S)-6-methyloxaalkyl exemestane compounds and related methods of use

6-Methyloxaalkyl exemestane compounds and related compositions, as can be used, chemotherapeutically, to inhibit growth and proliferation of cancer cells.

Derivatives of exemestane - Synthesis and evaluation of aromatase inhibition

The irreversible aromatase inhibitor exemestane (6) reacts with nitromethane and sodium ethanolate to yield the Michael adduct 9. The aldehyde 10 is obtained by Nef reaction of the nitro compound 9 and affords the 1,4-dihydropyridine (DHP) 11 by Hantzsch reaction using methyl β-aminocrotonate in acetic acid. The new compounds showed a reduced inhibitory potency towards aromatase (IC50 values: 9, 0.91 μM; 10, 2.5 μM; 11, 10 μM) compared to 6 (IC50 = 0.23 μM). The 1,4-DHP 11 was dehydrogenated with CAN or electrochemically (E1/2 = 1.18 V) to yield the corresponding pyridine 12.