881997-23-5Relevant academic research and scientific papers
MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 5: Carbon-substituted analogues at the C-2 position
Yoshida, Ken-Ichi,Nakayama, Kiyoshi,Kuru, Noriko,Kobayashi, Shozo,Ohtsuka, Masami,Takemura, Makoto,Hoshino, Kazuki,Kanda, Hiroko,Zhang, Jason Z.,Lee, Ving J.,Watkins, William J.
, p. 1993 - 2004 (2007/10/03)
A series of 4-oxo-4H-pyrido[1,2-a]pyrimidine derivatives, derivatized at the 2-position with carbon-linked substituents, were synthesized and evaluated for their ability to potentiate the activity of the fluoroquinolone levofloxacin (LVFX) and the anti-pseudomonas β-lactam aztreonam (AZT) in Pseudomonas aeruginosa. Palladium-catalyzed cross-coupling methods were applied for the incorporation of aliphatic and aromatic substituents.
