882033-92-3

Usage

Uses

Used in Pharmaceutical Industry:
3-Fluoro-4-methylene-1-piperidinecarboxylic acid tert-butyl ester is used as a key intermediate for the synthesis of various drugs. Its unique structure and reactivity allow for the development of new pharmaceutical compounds with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 3-Fluoro-4-methylene-1-piperidinecarboxylic acid tert-butyl ester serves as an essential intermediate in the production of agricultural chemicals. Its versatility in organic synthesis contributes to the creation of innovative agrochemicals designed to enhance crop protection and yield.
Used in Organic Synthesis:
3-Fluoro-4-methylene-1-piperidinecarboxylic acid tert-butyl ester is utilized as a valuable building block in organic synthesis. Its protective tert-butyl ester group and unique structure facilitate the synthesis of a wide range of organic compounds, expanding the scope of chemical research and development.
Used in Drug Development:
3-Fluoro-4-methylene-1-piperidinecarboxylic acid tert-butyl ester plays a crucial role in drug development, where its reactivity and potential for modification contribute to the discovery and design of new pharmaceutical agents. Its application in this field underscores its importance in advancing therapeutic options for various medical conditions.

Upstream product

• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 211108-50-8 tert-butyl-3-fluoro-4-oxopiperidine-1-carboxylate 
• 882033-91-2 3-fluoro-4-hydroxy-4-trimethylsilanylmethyl-piperidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 882033-96-7 (+/-)-cis-tert-butyl 1-{3-fluoro-4-[(methylsulfonyl)oxymethyl]piperidin-1-yl}carboxylate 
• 1303972-96-4 C₁₁H₂₁FN₂O₂ 
• 1303972-96-4 C₁₁H₂₁FN₂O₂ 
• 882033-96-7 tert-butyl 3-fluoro-4-{[(methylsulfonyl)oxy]methyl}piperidine-1-carboxylate 
• 1303973-77-4 tert-butyl 3-fluoro-4-(hydroxymethyl)piperidine-1-carboxylate 
• 882033-96-7 (+/-)-trans-tert-butyl 1-{3-fluoro-4-[(methylsulfonyl)oxymethyl]piperidin-1-yl}carboxylate 

Relevant academic research and scientific papers

Discovery of SARxxxx92, a pan-PIM kinase inhibitor, efficacious in a KG1 tumor model

N-substituted azaindoles were discovered as potent pan-PIM inhibitors. Lead optimization, guided by structure and focused on physico-chemical properties allowed us to solve inherent hERG and permeability liabilities, and provided compound 27, which subseq

Bridged Spiro[2.4]heptane Ester Derivatives

The invention relates to a method for preparing linear polymers having an amide end or having a star architecture comprising an amide core, by means of a ring opening using lactide and glycolide monomers or a lactide monomer ring in the presence of a cata

Synthesis and in vitro characterization of trans- and cis-[ 18F]-4-methylbenzyl 4-[(pyrimidin-2-ylamino)methyl]-3- fluoropiperidine-1-carboxylates as new potential PET radiotracer candidates for the NR2B subtype N-methyl-d-aspartate receptor

Diastereoisomeric compounds [18F]cis- and [18F]trans- 4-methylbenzyl 4-[(pyrimidin-2-ylamino)methyl]-3-fluoro-piperidine-1- carboxylates were successfully synthesized as new subtype-selective PET radiotracers for imaging the NR2B sub

BRIDGED SPIRO[2.4]HEPTANE ESTER DERIVATIVES

The present invention relates to bridged spiro[2.4]heptane ester derivatives of formula (I) wherein W, Y, R1 and R2 are as defined in the description, their preparation and their use as pharmaceutically active compounds.

Synthesis and SAR of substituted tetrahydrocarbazole derivatives as new NPY-1 antagonists

The SAR of a new series of tetrahydrocarbazole derivatives is described: the appropriate decoration of this template led to the identification of a new class of NPY-1 antagonists showing good in vitro potency and a promising in vivo pharmacokinetic profil