882033-96-7

Upstream product

• 1303973-77-4 tert-butyl 3-fluoro-4-(hydroxymethyl)piperidine-1-carboxylate 
• 124-63-0 methanesulfonyl chloride 
• 882033-92-3 tert-butyl 1-[3-fluoro-4-methylenepiperidin-1-yl]carboxylate 
• 895578-00-4 1-benzyl-3-fluoro-4-(hydroxymethyl)pyridin-1-ium bromide 
• 372-47-4 3-Fluoropyridine 
• 870063-60-8 3-fluoro-4-(hydroxymethyl)pyridine 
• 882033-93-4 (3S,4R)-tert-butyl 3-fluoro-4-(hydroxymethyl)piperidine-1-carboxylate 
• 895577-96-5 ((3S,4R)-3-fluoropiperidin-4-yl)methanol hydrochloride 
• 895578-01-5 1-benzyl-3-fluoro-4-hydroxymethyl-1,2,5,6-tetrahydropyridine hydrochloride 
• 882033-93-4 (±)-cis-tert-butyl 1-[3-fluoro-4-(hydroxymethyl)piperidin-1-yl]carboxylate 
• 211108-50-8 tert-butyl-3-fluoro-4-oxopiperidine-1-carboxylate 
• 882033-91-2 3-fluoro-4-hydroxy-4-trimethylsilanylmethyl-piperidine-1-carboxylic acid tert-butyl ester 
• 882033-93-4 (±)-trans-tert-butyl 1-[3-fluoro-4-(hydroxymethyl)piperidin-1-yl]carboxylate 

Relevant academic research and scientific papers

QUINAZOLINONES AS PARP14 INHIBITORS

The present invention relates to quinazolinones and related compounds which are inhibitors of PARP14 and are useful, for example, in the treatment of cancer and inflammatory diseases.

PYRIMIDINE AND TRIAZINE DERIVATIVES AND THEIR USE AS AXL INHIBITORS

Compounds of the general formula(I): (I) processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

BICYCLIC AZAHETEROCYCLIC COMPOUNDS AS NR2B NMDA RECEPTOR ANTAGONISTS

Disclosed are chemical entities of Formula (I): wherein R1 and Z are defined herein, as NR2B subtype selective receptor antagonists. Also disclosed are pharmaceutical compositions comprising a chemical entity of Formula (I), and methods of treating various diseases and disorders associated with NR2B antagonism, e.g., diseases and disorders of the CNS, such as depression, by administering a chemical entity of Formula (I).

Synthesis and in vitro characterization of trans- and cis-[ 18F]-4-methylbenzyl 4-[(pyrimidin-2-ylamino)methyl]-3- fluoropiperidine-1-carboxylates as new potential PET radiotracer candidates for the NR2B subtype N-methyl-d-aspartate receptor

Diastereoisomeric compounds [18F]cis- and [18F]trans- 4-methylbenzyl 4-[(pyrimidin-2-ylamino)methyl]-3-fluoro-piperidine-1- carboxylates were successfully synthesized as new subtype-selective PET radiotracers for imaging the NR2B sub

Synthesis and SAR of substituted tetrahydrocarbazole derivatives as new NPY-1 antagonists

The SAR of a new series of tetrahydrocarbazole derivatives is described: the appropriate decoration of this template led to the identification of a new class of NPY-1 antagonists showing good in vitro potency and a promising in vivo pharmacokinetic profil