882039-02-3

Basic information

• Product Name: 2-(2-formyl-4-oxo-4H-quinazolin-3-yl)-benzoic acid
• Synonyms: 2-(2-formyl-4-oxo-4H-quinazolin-3-yl)-benzoic acid
• CAS NO: 882039-02-3
• Molecular Weight: 294.266
• Mol File: 882039-02-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(2-formyl-4-oxo-4H-quinazolin-3-yl)-benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-formyl-4-oxo-4H-quinazolin-3-yl)-benzoic acid(882039-02-3)
• EPA Substance Registry System: 2-(2-formyl-4-oxo-4H-quinazolin-3-yl)-benzoic acid(882039-02-3)

Safety Data

• Hazardous Substances Data: 882039-02-3(Hazardous Substances Data)

Upstream product

• 118-92-3 anthranilic acid 
• 525-76-8 2-methyl-4-oxo-3,1-benzoxazine 
• 4005-06-5 2-(2-methyl-4-oxo-4H-quinazolin-3-yl)-benzoic acid 

Relevant articles and documents

New development of Meyers' methodology: Stereoselective preparation of an axially chiral 5,7-fused bicyclic lactam related to circumdatins/benzomalvins and asperlicins

The stereoselective preparation of a new Meyers' bicyclic lactam-bridged biaryl 1, highly structurally related to circumdatins, benzomalvins and asperlicins, is reported. Using the popular Meyers' diastereoselective lactamization, under dehydrating conditions (CH2Cl 2/reflux/MgSO4), trans-(aS,R,S)-1 was obtained in a rather modest yield of 25% and an excellent diastereoselectivity >95%. An alternative procedure making use of the activating agents of carboxylic acid (Mukaiyama reagent and FEP) allowed the lactamization process to take place under milder conditions (CH2Cl2/20°C) affording trans-(aS,R,S)-1 in fairly good yields (50%-85%) and in up to 65% de.