882067-51-8

Basic information

• Product Name: 2-(4-chlorophenyl)-3-acetyl-5-(4-nitrophenyl)-2,3-dihydro-1,3,4-oxadiazole
• CAS NO: 882067-51-8
• Molecular Weight: 345.742
• Mol File: 882067-51-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(4-chlorophenyl)-3-acetyl-5-(4-nitrophenyl)-2,3-dihydro-1,3,4-oxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-chlorophenyl)-3-acetyl-5-(4-nitrophenyl)-2,3-dihydro-1,3,4-oxadiazole(882067-51-8)
• EPA Substance Registry System: 2-(4-chlorophenyl)-3-acetyl-5-(4-nitrophenyl)-2,3-dihydro-1,3,4-oxadiazole(882067-51-8)

Safety Data

• Hazardous Substances Data: 882067-51-8(Hazardous Substances Data)

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 636-97-5 N-amino-(4-nitrophenyl)carboxamide 
• 51771-31-4 4-Nitro-benzoic acid [1-(4-chloro-phenyl)-meth-(E)-ylidene]-hydrazide 
• 108-24-7 acetic anhydride 

Relevant articles and documents

3-Acetyl-2,5-diaryl-2,3-dihydro-1,3,4-oxadiazoles: A new scaffold for the selective inhibition of monoamine oxidase B

3-Acetyl-2,5-diaryl-2,3-dihydro-1,3,4-oxadiazoles were designed, synthesized, and tested as inhibitors against human monoamine oxidase (MAO) A and B isoforms. Several compounds, obtained as racemates, were identified as selective MAO-B inhibitors. The enantiomers of some derivatives were separated by enantioselective HPLC and tested. The R-enantiomers always showed the highest activity. Docking study and molecular dynamic simulations demonstrated the putative binding mode. We conclude that these 1,3,4-oxadiazoles derivatives are promising reversible and selective MAO-B inhibitors.