88207-35-6Relevant academic research and scientific papers
Synthesis of 6H-isoindolo[2,1-a]indol-6-ones via Pd-catalyzed cycloaminocarbonylation of 2-(1H-indol-2-yl)phenyl tosylates with CO
Liu, Bin,Lai, Chunbo,Zhang, Chunlei,Zhou, Xigeng
, p. 752 - 757 (2018)
An efficient method for preparation of substituted 6H-isoindolo[2,1-a]indol-6-ones (2) that are important structural components of a vast array of naturally occurring and pharmacologically active compounds, has been developed by the palladium-catalyzed in
Isoindolo[2,1-a]indol-6-one-a new pyrolytic synthesis and some unexpected chemical properties
Crawford, Lynne A.,Clemence, Nathan C.,McNab, Hamish,Tyas, Richard G.
experimental part, p. 2334 - 2339 (2009/02/02)
Isoindolo[2,1-a]indol-6-one 1 is formed by a sigmatropic shift-elimination-cyclisation cascade by flash vacuum pyrolysis (FVP) of methyl 2-(indol-1-yl)benzoate 7 at 950 °C. The dihydro compound 16 is easily obtained by catalytic reduction of 1, but the reaction is very sensitive to steric effects at the 11-position. Attempted ring-opening of 1 in basic methanol provides an equilibrium of isoindolo[2,1-a]indol-6-one 1 and the ester 19. Lithium aluminium hydride reduction of 1 provides the alcohol 22 which can be dehydrated to a mixture of 23 and 24 by FVP at 800-950 °C.
Structure-activity relationships of 2-aryl-1H-indole inhibitors of the NorA efflux pump in Staphylococcus aureus
Ambrus, Joseph I.,Kelso, Michael J.,Bremner, John B.,Ball, Anthony R.,Casadei, Gabriele,Lewis, Kim
scheme or table, p. 4294 - 4297 (2009/04/06)
The synthesis of 22 2-aryl-1H-indoles, including 12 new compounds, has been achieved via Pd- or Rh-mediated methodologies, or selective electrophilic substitution. All three methods were based on elaborations from simple indole precursors. SAR studies on
Indole β-Nucleophilic Substitution. Part 7. β-Halogenation of Indoles. Attempted Intramolecular β-Nucleophilic Substitution of α-Arylindoles
Dalton, Lesley,Humphrey, Godfred L.,Cooper, Melanie M.,Joule, John A.
, p. 2417 - 2422 (2007/10/02)
Intramolecular β-nucleophilic substitution of 2-aryl-1-phenylsulphonylindoles could not be achieved.N-Arylsulphonylation of 2-arylindoles with arylsulphonyl halides using phase-transfer conditions is accompanied by 3-halogenation in some cases; the propor
