882172-48-7Relevant academic research and scientific papers
Synthesis of Tic-D-Phe Ψ[CH2-CH2] isostere and its use in the development of melanocortin receptor agonists
Tian, Xinrong,Chen, Xuemei,Gan, Lixian,Hayes, Jeffery C.,Switzer, Adrian G.,Solinsky, Mark G.,Ebetino, Frank H.,Wos, John A.,Pinney, Beth B.,Farmer, Julie A.,Crossdoersen, Doreen,Sheldon, Russell J.
, p. 1721 - 1725 (2007/10/03)
The first synthesis of Tic-d-Phe Ψ[CH2-CH2] isostere is described, which features diastereoselective alkylation of the tricyclic lactam 14. The use of this novel dipeptide isostere in the development of melanocortin agonists has been
