882187-82-8

Upstream product

• 40273-52-7 2-(2-chloro-3-fluoropyridin-4-yl)propan-2-ol 
• 17282-04-1 2-chloro-3-fluoropyridine 
• 628322-95-2 2-(3-bromo-8-fluoroimidazo[1,2-a]pyridin-7-yl)propan-2-ol 
• 628322-91-8 2-(8-fluoroimidazo[1,2-a]pyridin-7-yl)propan-2-ol 
• 425378-72-9 2'-fluoro-5'-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)biphenyl-2-carbonitrile 
• 628323-00-2 3-bromo-8-fluoro-7-[2-(triethylsilyloxy)prop-2-yl]imidazo[1,2-a]pyridine 

Relevant academic research and scientific papers

8-Fluoroimidazo[1,2-a]pyridine: Synthesis, physicochemical properties and evaluation as a bioisosteric replacement for imidazo[1,2-a]pyrimidine in an allosteric modulator ligand of the GABAA receptor

8-Fluoroimidazo[1,2-a]pyridine has been established as a physicochemical mimic of imidazo[1,2-a]pyrimidine, using both in silico and traditional techniques. Furthermore, a novel synthesis of a 3,7-disubstituted-8- fluoroimidazopyridine 3 has been developed and the utility of the physicochemical mimicry has been demonstrated in an in vitro system. Here, the 8-fluoroimidazopyridine ring contained in ligand 3 acts as a bioisosteric replacement for imidazopyrimidine in the GABAA receptor modulator 2.