882305-14-8

Basic information

• Product Name: 4-Thiazolecarboxylicacid,2-(2-methylpropyl)-,ethylester(9CI)
• Synonyms: 4-Thiazolecarboxylicacid,2-(2-methylpropyl)-,ethylester(9CI);ethyl 2-isobutylthiazole-4-carboxylate
• CAS NO: 882305-14-8
• Molecular Formula: C₁₀H₁₅NO₂S
• Molecular Weight: 213.3
• Product Categories: THIAZOLE
• Mol File: 882305-14-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 285.7±13.0 °C(Predicted)
• Appearance: /
• Density: 1.106±0.06 g/cm3(Predicted)
• PKA: 0.90±0.10(Predicted)
• CAS DataBase Reference: 4-Thiazolecarboxylicacid,2-(2-methylpropyl)-,ethylester(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Thiazolecarboxylicacid,2-(2-methylpropyl)-,ethylester(9CI)(882305-14-8)
• EPA Substance Registry System: 4-Thiazolecarboxylicacid,2-(2-methylpropyl)-,ethylester(9CI)(882305-14-8)

Safety Data

• Hazardous Substances Data: 882305-14-8(Hazardous Substances Data)

Upstream product

• 541-46-8 isobutylamide 
• 16536-95-1 3-methylbutanethioamide 
• 70-23-5 ethyl Bromopyruvate 

Relevant articles and documents

Synthesis of (4R,5S)-melithiazols F and I

Palladium-catalyzed cyclization-methoxycarbonylation of (2R,3S)-3-methylpenta-4-yne-1,2-diol (8) derived from the (2R,3S)-epoxybutanoate 7 followed by methylation gave the tetrahydro-2-furylidene acetate (-)-9, which was converted into the left-half aldehyde (+)-4. A Wittig reaction between (+)-4 and the phosphoranylide derived from the bithiazole-type phosphonium iodide 5 using lithium bis(trimethylsilyl)-amide afforded (+)-(4R,5S)- melithiazol F (1), whose spectroscopic data were identical with those of the natural product 1. Moreover, the synthesis of (+)-(4R,5S)-melithiazol I (2), was achieved by the same synthetic strategy as that of (+)-(4R,5S)-melithiazol F (1). The antifungal activity of the synthetic melithiazols F (1) and I (2) against the phytopathogenic fungus, Phytophthora capsici, was evaluated by using a paper disc assay method. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.