541-46-8Relevant articles and documents
MODIFIED PEPTIDES AND THEIR USE
-
Paragraph 0081; 0084; 0099-0100, (2020/05/13)
The invention relates to a compound of formula (A) wherein n is an integer from 1 to 6, and R1, R1', R2, R2', R3, R3' are cationic or hydrophobic residues.
Appraisal of Ruthenium(II)complexes of (4-phenoxyphenylazo)ligands for the synthesis of primary amides by dint of hydroxylamine hydrochloride and aldehydes
Vinoth, Govindasamy,Indira, Sekar,Bharathi, Madheswaran,Sounthararajan, Muniyan,Sakthi, Dharmalingam,Bharathi, Kuppannan Shanmuga
, p. 67 - 77 (2019/05/22)
A new family of O, N donor-functionalized (4-phenoxyphenylazo)-2-naphthol/4-substituted phenol-based ligands (HL1-HL4)has been synthesized. The prepared ligands were successfully utilized for the access of a series of ruthenium(II)carbonyl complexes of the type [Ru(L)Cl(CO)(EPh3)3](E = phosphine/arsine), (L = 1-(4-phenoxyphenylazo)-2-naphthol (HL1), 2-(4-phenoxyphenylazo)-4-chlorophenol (HL2), 2-(4-phenoxyphenylazo)-4-methylphenol (HL3)and 2-(4-phenoxyphenylazo)-4-methoxyphenol (HL4)). All of the ruthenium(II)carbonyl complexes and ligands have been fully characterized by FT-IR, UV–visible, 1H NMR, 31P NMR, mass spectrometry and CHN analysis. The ligands have been analyzed by 13C NMR. The UV–visible spectroscopic study reveals that both the ligands and Ru(II)complexes exhibit excellent charge transfer transitions. This is the basic criteria for the oxidative amidation reaction, which is an influential strategy for the transformation of oxygenated organic compounds to the profitable amides. However, this catalytic process makes more impact on the application of new divalent ruthenium(II)azo compounds as catalyst in a single-pot conversion of aldehydes to amides in the presence of NaHCO3.
Studies on the synthesis of peptides containing dehydrovaline and dehydroisoleucine based on copper-mediated enamide formation
Gille, Franziska,Kirschning, Andreas
supporting information, p. 564 - 570 (2016/04/08)
The preparation of peptide fragments containing dehydrovaline and dehydroisoleucine moieties present in the antibiotic myxovalargin is reported. Peptide formation is based on a copper-mediated C-N cross-coupling protocol between an acyl amide and a peptidic vinyl iodide. The presence of a neighboring arginine in the vinyl iodide posed a challenge with respect to the choice of the protecting group and the reaction conditions. It was found that ornithine - a suitable precursor - is better suited than arginine for achieving good yields for the C-N cross-coupling reaction. The optimized conditions were utilized for the synthesis of peptides 32, 33, 39 and 40 containing a neighboring ornithine as well as for the tripeptide 44 containing dehydroisoleucine with the correct stereochemistry.
