882402-13-3

Usage

Uses

Used in Pharmaceutical Industry:
[1,1’-bi(cyclopropan)]-1-amine hydrochloride is used as a chiral ligand for the synthesis of various pharmaceuticals. Its application is crucial in the development of enantiomerically pure drugs, which are essential for ensuring the desired therapeutic effects and minimizing potential side effects.
Used in Organic Chemistry Research:
In the field of organic chemistry, [1,1’-bi(cyclopropan)]-1-amine hydrochloride is used as a catalyst to facilitate numerous chemical reactions. Its role in enhancing reaction rates and selectivity makes it a valuable tool for researchers working on the synthesis of complex organic molecules.
Used in Fine Chemicals Production:
[1,1’-bi(cyclopropan)]-1-amine hydrochloride is also employed in the production of fine chemicals, which are high-purity chemicals used in various industries, such as fragrances, flavors, and specialty chemicals. Its unique reactivity and chiral properties contribute to the development of novel synthetic routes and the improvement of existing processes.
Used in Catalyst Development:
[1,1’-bi(cyclopropan)]-1-amine hydrochloride is utilized in the development of new catalysts for various industrial applications. Its ability to act as a chiral ligand makes it a promising candidate for the design of catalysts that can selectively promote specific reactions, leading to more efficient and environmentally friendly processes.

Upstream product

• 925-90-6 ethylmagnesium bromide 
• 5500-21-0 cyclopropropanecarbonitrile 
• 1321831-90-6 tert-butyl 1-(cyclopropyl)cyclopropylcarbamate 

Downstream Products

• 1215105-33-1 5-(5-(bi(cycloprop)ylcarbamoyl)-4-methoxy-2-methylphenyl)-4-fluoro-2-(4-fluorophenyl)-N-methylpyrazolo[1,5-a]pyridine-3-carboxamide 
• 913194-94-2 2-amino-N-bicyclopropyl-1-yl-5-cyano-3-methylbenzamide 
• 913194-95-3 2-(3-chloropyridin-2-yl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid [2-(bicyclopropyl-1-ylcarbamoyl)-4-iodo-6-methylphenyl]amide 
• 1187874-10-7 2-amino-N-(bicyclopropyl-1-yl)-benzamide 

Relevant academic research and scientific papers

IMIDAZO [1,5-A]PYRIMIDINYL CARBOXAMIDE COMPOUNDS AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS

The invention provides substituted imidazo[1,5-a]pyrimidinyl carboxamide and related organic compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical disorders, e.g., Gaucher disease, Parkinson's disease, Lewy body disease, dementia, or multiple system atrophy, in a patient. Exemplary substituted imidazo[1,5-a]pyrimidinyl carboxamide compounds described herein include substituted 2-heterocyclyl-4-alkyl-imidazo[1,5-a]pyrirnidine-8-carboxamide compounds and variants thereof.

PYRAZOLO[1,5-A]PYRIMIDINYL CARBOXAMIDE COMPOUNDS AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS

The invention provides substituted pyrazolo[1,5-a]pyrimidinyl carboxamide and related organic compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical disorders, e.g., Gaucher disease, Parkinson's disease, Lewy body disease, dementia, or multiple system atrophy, in a patient. Exemplary substituted pyrazolo[1,5-a]pyrimidinyl carboxamide compounds described herein include 2-heterocyclyl-4-alkyl-pyrazolo[1,5-a]pyrirnidine-3-carboxarnide compounds and variants thereof.

Scalable synthesis of (1-cyclopropyl)cyclopropylamine hydrochloride

1-Cyclopropylcyclopropanecarboxylic acid (2), which is accessible on a large scale (900 mmol) from 1-bromo-1-cyclopropylcyclopropane (1) in 64% yield (89% on a 12.4 mmol scale), has been subjected to a Curtius degradation employing the Weinstock protocol to furnish the N-Boc-protected (1-cyclopropyl)cyclopropylamine 3 (76%). Deprotection of 3 with hydrogen chloride in diethyl ether gave the (1-cyclopropyl)cyclopropylamine hydrochloride (4?HCl) in 87% yield.

Novel Insecticides

Compounds of formula I wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts and all stereoisomers and tautomeric forms of the compounds of formula I can be used as agrochemical active ingredients and can be prepared