88246-66-6

Basic information

• Product Name: 1,1-BIS(TRIMETHYLSILYLOXY)-3-METHYL-1-BUTENE
• Synonyms: 1,1-BIS(TRIMETHYLSILYLOXY)-3-METHYL-1-BUTENE
• CAS NO: 88246-66-6
• Molecular Formula: C₁₁H₂₆O₂Si₂
• Molecular Weight: 246.49
• Mol File: 88246-66-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 75 °C (12 mmHg)
• Flash Point: 25 °C
• Appearance: /
• Refractive Index: 1.415-1.417
• Storage Temp.: 0-6°C
• CAS DataBase Reference: 1,1-BIS(TRIMETHYLSILYLOXY)-3-METHYL-1-BUTENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1-BIS(TRIMETHYLSILYLOXY)-3-METHYL-1-BUTENE(88246-66-6)
• EPA Substance Registry System: 1,1-BIS(TRIMETHYLSILYLOXY)-3-METHYL-1-BUTENE(88246-66-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-10
• Safety Statements: 37/39-26-16
• Hazardous Substances Data: 88246-66-6(Hazardous Substances Data)

Upstream product

• 503-74-2 3-methylbutyric acid 
• 75-77-4 chloro-trimethyl-silane 

Downstream Products

• 3508-94-9 3-methyl-2-phenylbutyric acid 
• 144381-85-1 3-Methyl-2-[phenyl-(toluene-4-sulfonylamino)-methyl]-butyric acid methyl ester 
• 108004-71-3 2-(3-phenoxyphenyl)isovaleric acid 
• 4026-18-0 2-hydroxy-3-methylbutanoic acid 
• 88834-78-0 2-(Diphenylmethyl)-3-methylbuttersaeure 

Relevant articles and documents

An efficient α-hydroxylation of carbonyls using the HOF·CH3CN complex

The complex HOF·CH3CN, made directly from fluorine and aqueous acetonitrile, was used for α-hydroxylation of various ketones, esters and acids via their trimethyl silyl enol ethers. The reaction is usually complete in a few minutes at room temperature or below and has high yields.

METHYLENECYCLOHEXANE ANNULATION. TOTAL SYNTHESIS OF (+/-)-AXAMIDE-1, (+/-)-AXISONITRILE-1, AND THE CORRESPONDING C-10 EPIMERS

Conjugate addition of 2-(5-chloro-1-pentenyl)magnesium bromide (12) to 2-methyl-2-cyclopenten-1-one (6), followed by intramolecular alkylation of the resultant product, afforded (85percent) the bicyclic ketone 7, which was transformed (77percent) into the enone 16.Titanium tetrachloride-catalyzed conjugate addition of 3-methyl-1,1-bis(trimethylsiloxy)-1-butene to 16 gave (93percent) a 3:2 mixture of the keto acids 20 and 21, which were separated.Compound 20, the stereochemistry of wich was confirmed by a single-crystal X-ray analysis, was converted into (+/-)-axamide-1 (1) and (+/-)-axisonitrile-1 (2), while 21 was transformed into the corresponding C-10 epimers 8 and 9, respectively.