882499-87-8

Basic information

• Product Name: METHYL 2-AMINO-5-BROMO-4-PYRIDINECARBOXYLATE
• Synonyms: METHYL 2-AMINO-5-BROMO-4-PYRIDINECARBOXYLATE;METHYL 2-AMINO-5-BROMOPYRIDINE-4-CARBOXYLATE;METHYL 2-AMINO-5-BROMOISONICOTINATE;Methyl 2-amino-5-bromoisonicotinate 98%;Methyltinate 2-amino-5-bromoisonico;Methyl 2-amino-5-bromopyridine-4-carboxylate, 2-Amino-5-bromo-4-(methoxycarbonyl)pyridine;2-AMino-5-broMoisonicotinic acid Methyl ester;4-Pyridinecarboxylic acid, 2-aMino-5-broMo-, Methyl ester
• CAS NO: 882499-87-8
• Molecular Formula: C₇H₇BrN₂O₂
• Molecular Weight: 231.04668
• EINECS: 1533716-785-6
• Product Categories: blocks;Bromides;Carboxes;Pyridines
• Mol File: 882499-87-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 311.5 °C at 760 mmHg
• Flash Point: 142.2 °C
• Appearance: /
• Density: 1.662 g/cm³
• Vapor Pressure: 0.000562mmHg at 25°C
• Refractive Index: 1.607
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 2.78±0.24(Predicted)
• CAS DataBase Reference: METHYL 2-AMINO-5-BROMO-4-PYRIDINECARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 2-AMINO-5-BROMO-4-PYRIDINECARBOXYLATE(882499-87-8)
• EPA Substance Registry System: METHYL 2-AMINO-5-BROMO-4-PYRIDINECARBOXYLATE(882499-87-8)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 882499-87-8(Hazardous Substances Data)

Usage

Description

METHYL 2-AMINO-5-BROMO-4-PYRIDINECARBOXYLATE is a chemical compound with the molecular formula C7H7BrN2O2, derived from pyridine and featuring a methyl, amino, and carboxylate group. It is utilized as an intermediate in the synthesis of pharmaceuticals and organic compounds, and its structural properties and functional groups make it a promising candidate for further chemical modifications in medicinal chemistry.

Uses

Used in Pharmaceutical Synthesis:
METHYL 2-AMINO-5-BROMO-4-PYRIDINECARBOXYLATE is used as an intermediate in the synthesis of pharmaceuticals for its ability to be chemically modified, contributing to the development of new drugs.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, METHYL 2-AMINO-5-BROMO-4-PYRIDINECARBOXYLATE is used as a research compound to explore its potential biological activities and structural properties, aiding in drug discovery and development.
Used in Organic Compounds Synthesis:
METHYL 2-AMINO-5-BROMO-4-PYRIDINECARBOXYLATE is also used as an intermediate in the synthesis of various organic compounds, leveraging its functional groups for creating a range of chemical products.

InChI:InChI=1/C7H7BrN2O2/c1-12-7(11)4-2-6(9)10-3-5(4)8/h2-3H,1H3,(H2,9,10)

Upstream product

• 6937-03-7 methyl 2-aminoisonicotinate 

Downstream Products

• 1278407-60-5 methyl 6-bromo-2-phenylimidazo[1,2-a]pyridine-7-carboxylate 
• 1278407-29-6 4-(Azetidine-1-carbonyl)-2-methyl-2H-pyrazole-3-carboxylic acid (6-bromo-2-phenyl-imidazo[1,2-a]pyridin-7-yl)-amide 
• 1278407-36-5 4-(Azetidine-1-carbonyl)-2-methyl-2H-pyrazole-3-carboxylic acid (6-cyclopropyl-2-phenyl-imidazo[1,2-a]pyridin-7-yl)-amide 
• 1278407-61-6 6-bromo-2-phenylimidazo[1,2-a]pyridine-7-carboxylic acid 
• 1278407-62-7 (6-bromo-2-phenyl-imidazo[1,2-a]pyridin-7-yl)-carbamic acid tert-butyl ester 
• 1278407-63-8 6-bromo-2-phenyl-imidazo[1,2-a]pyridin-7-ylamine 
• 1278407-64-9 5-(6-bromo-2-phenyl-imidazo[1,2-a]pyridin-7-ylcarbamoyl)-1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester 
• 1278407-65-0 5-(6-bromo-2-phenyl-imidazo[1,2-a]pyridin-7-ylcarbamoyl)-1-methyl-1H-pyrazole-4-carboxylic acid 
• 1278407-71-8 (6-cyclopropyl-2-phenyl-imidazo[1,2-a]pyridin-7-yl)-carbamic acid tert-butyl ester 
• 1278407-72-9 6-cyclopropyl-2-phenyl-imidazo[1,2-a]pyridin-7-ylamine 
• 1227586-36-8 2-amino-5-bromo-4-pyridinemethanol 

Relevant articles and documents

THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS

Disclosed herein are certain thiadiazolyl derivatives Formula (I): that inhibit DNA Polymerase Theta (Polθ) activity, in particular inhibit Polθ activity by inhibiting ATP dependent helicase domain activity of Polθ. Also, disclosed are pharmaceutical compositions comprising such compounds and methods of treating and/or preventing diseases treatable by inhibition of Polθ such as cancer, including homologous recombination (HR) deficient cancers.

Bisaryl-sulfonamides

Compounds, compositions and methods are provided that are useful in the treatment or prevention of a condition or disorder mediated by PPARγ or PPARδ. In particular, the compounds of the invention modulate the function of PPARγ or PPARδ. The subject methods are particularly useful in the treatment and/or prevention of diabetes, obesity, hypercholesterolemia, rheumatoid arthritis and atherosclerosis.