882508-75-0Relevant academic research and scientific papers
A New Approach to the Synthesis of 1-Arylbenzimidazole-2-thiones from Nitroarenes and Anilines through Halogen-Free Substitution of Hydrogen via Iminophosphorane Intermediates
?ukasik, Emilia,Wróbel, Zbigniew
, p. 263 - 270 (2016/01/15)
2-(Arylamino)phenyliminophosphoranes, formed directly from 2-nitrosodiarylamines, undergo a high-yielding cyclocondensation with CS2, providing a variety of 1-arylbenzimidazole-2-thiones. The reaction concludes a new synthetic route leading to the title compounds from simple nitroarenes and arylamines. The protocol is superior to common methods that use N-arylarylenediamines because it omits the SNAr substitution of halogen atoms in ortho-halonitroarenes, as well as reduction processes required for the synthesis of the intermediate diamines.
RECEPTOR FUNCTION REGULATING AGENT
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Page/Page column 34, (2010/11/28)
The present invention relates to a GPR40 receptor function regulator comprising a fused imidazole compound represented by the formula: wherein each symbol is as defined in the specification, or a salt thereof or a prodrug thereof. The GPR40 receptor funct
