882517-92-2

Usage

Uses

Used in Organic Synthesis:
9-Bromo-6H-[1,2,4]triazolo[1,5-c]quinazolin-5-one is used as a synthetic intermediate for the creation of various organic compounds. Its unique structure and functional groups facilitate multiple chemical reactions, making it a valuable component in the synthesis of new molecules with potential applications in various industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 9-Bromo-6H-[1,2,4]triazolo[1,5-c]quinazolin-5-one is used as a key building block in the development of novel drugs. Its heterocyclic rings and functional groups can be modified to create new pharmaceutical agents with specific therapeutic properties, targeting a range of diseases and medical conditions.
The properties, safety data, and potential toxicological characteristics of 9-Bromo-6H-[1,2,4]triazolo[1,5-c]quinazolin-5-one are typically industry-specific, and its assessment often requires advanced chemical analysis to ensure safe and effective use in various applications.

Upstream product

• 220269-80-7 ethyl (4-bromo-2-cyanophenyl)carbamate 
• 624-84-0 formic acid hydrazide 

Downstream Products

• 882517-93-3 4-bromo-2-(2H-[1,2,4]triazol-3-yl)-phenylamine 

Relevant academic research and scientific papers

The discovery and unique pharmacological profile of RO4938581 and RO4882224 as potent and selective GABAA α5 inverse agonists for the treatment of cognitive dysfunction

Lead optimisation of the imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepine class led to the identification of two clinical leads [RO4882224 (11) and RO4938581 (44)] functioning as novel potent and selective GABAA α5 inverse agonists. The unique pharmacological profiles and optimal pharmacokinetic profiles resulted in in vivo activity in selected cognition models.

Substituted imidazol[1,5-A][1,2,4]triazolo[1,5-D][1,4]benzodiazepine derivatives

The present invention is concerned with substituted imidazo[1,5-a][1,2,4]triazolo[1,5-d][1,4]benzodiazepine derivatives of formula I wherein R1 is hydrogen, halogen, lower alkyl, lower alkynyl, cycloalkyl, heterocycloalkyl, benzyl, cyano, lower

Halogen substituted imidazol[1,5-A][1,2,4]triazolo[1,5-D][1,4]benzodiazepine derivatives

The invention relates to halogen substituted imidazo[1,5-a][1,2,4]triazolo[1,5-d][1,4]benzodiazepine derivatives of formula I wherein R1, R2, R3, R4 and n are as defined in the specification and to pharmaceutica

Substituted imidazo[1,5-a][1,2,4]triazolo[1,5-d][1,4]benzodiazepine derivatives

The present invention is concerned with a method of treating a disease selected from the group consisting of cognitive disorders, anxiety, Alzheimer's disease, and schizophrenia comprising administering a therapeutically effective amount of a substituted