882562-42-7Relevant articles and documents
Synthesis and SAR of aminopyrimidines as novel c-Jun N-terminal kinase (JNK) inhibitors
Alam, Mahbub,Beevers, Rebekah E.,Ceska, Tom,Davenport, Richard J.,Dickson, Karen M.,Fortunato, Mara,Gowers, Lewis,Haughan, Alan F.,James, Lynwen A.,Jones, Mark W.,Kinsella, Natasha,Lowe, Christopher,Meissner, Johannes W.G.,Nicolas, Anne-Lise,Perry, Benjamin G.,Phillips, David J.,Pitt, William R.,Platt, Adam,Ratcliffe, Andrew J.,Sharpe, Andrew,Tait, Laura J.
, p. 3463 - 3467 (2007)
The development of a series of novel aminopyrimidines as inhibitors of c-Jun N-terminal kinases is described. The synthesis, in vitro inhibitory values for JNK1, JNK2 and CDK2, and the in vitro inhibitory value for a c-Jun cellular assay are discussed.
