88260-15-5Relevant academic research and scientific papers
General and mild preparation of 2-aminopyridines
Londregan, Allyn T.,Jennings, Sandra,Wei, Liuqing
, p. 5254 - 5257 (2010)
A general and facile one-pot amination procedure for the synthesis of 2-aminopyridines from the corresponding pyridine-N-oxides is presented as a mild alternative to SNAr chemistry. A variety of amines and heterocyclic-N-oxides participate effectively in this transformation which uses the phosphonium salt, PyBroP, as a means of substrate activation.
