88264-65-7

Usage

Uses

Used in Pharmaceutical Industry:
DITHIOBIS[2-AMINO-4-METHYLPENTANE] DIHYDROCHLORIDE is used as a pharmaceutical agent for its inhibitory effects on leucine aminopeptidase. This property makes it a potential candidate for the development of drugs targeting various diseases and conditions where leucine aminopeptidase plays a significant role.
Used in Research Applications:
In the field of research, DITHIOBIS[2-AMINO-4-METHYLPENTANE] DIHYDROCHLORIDE serves as a valuable tool for studying the function and regulation of leucine aminopeptidase. Its potent inhibitory activity allows researchers to investigate the enzyme's role in biological processes and its potential as a therapeutic target.
Used in Drug Development:
DITHIOBIS[2-AMINO-4-METHYLPENTANE] DIHYDROCHLORIDE can be utilized in the development of novel drugs targeting leucine aminopeptidase. Its ability to inhibit the enzyme's activity makes it a promising starting point for designing new therapeutic agents that can modulate the enzyme's function and treat related diseases.

InChI:InChI=1/C6H15NS/c1-5(2)3-6(7)4-8/h5-6,8H,3-4,7H2,1-2H3/t6-/m0/s1

Upstream product

• 23852-57-5 (S)-2-(2-Methylpropyl)-aziridine 
• 13892-89-2 (S)-1-(bromomethyl)-3-methylbutylammonium bromide 
• 7533-40-6 (S)-2-amino-4-methylpentan-1-ol 

Downstream Products

• 101250-21-9 *,R^*)>-phenylmethyl 2-<<<1-<<(2-amino-2-oxoethyl)thio>methyl>-3-methylbutyl>amino>methyl>-1-pyrrolidinecarboxylate hydrochloride 
• 101250-65-1 (S)-2-((S)-1-tert-Butoxycarbonylmethanesulfonylmethyl-3-methyl-butylcarbamoyl)-pyrrolidine-1-carboxylic acid benzyl ester 
• 101250-61-7 (S)-2-((S)-1-tert-Butoxycarbonylmethylsulfanylmethyl-3-methyl-butylcarbamoyl)-4-oxo-pyrrolidine-1-carboxylic acid benzyl ester 
• 101250-63-9 (S)-2-((S)-1-tert-Butoxycarbonylmethylsulfanylmethyl-3-methyl-butylcarbamoyl)-5-oxo-pyrrolidine-1-carboxylic acid benzyl ester 
• 101250-25-3 *,R^*)>-phenylmethyl 2-<<<1-<<(carboxymethyl)sulfonyl>methyl>-3-methylbutyl>amino>carbonyl>-1-pyrrolidinecarboxylate 
• 101250-60-6 *,R^*)>-phenylmethyl 2-<<<1-<<<2-(1,1-dimethylethoxy)-2-oxoethyl>thio>methyl>-3-methylbutyl>amino>carbonyl>-1-pyrrolidinecarboxylate 
• 101250-68-4 [S-(R*,R*)]-2-[[[1-[[(2-Amino-2-oxoethyl)thio]methyl]-3-methylbutyl][(1,1-Dimethylethoxy)carbonyl]amino]methyl]-1-[pyrrolidine]carboxylic acid, phenylmethyl ester 
• 101250-26-4 *,R^*)>-phenylmethyl 2-<<<1-<<(carboxymethyl)thio>methyl>-3-methylbutyl>amino>carbonyl>-5-oxo-1-pyrrolidinecarboxylate 
• 101250-24-2 *,R^*)>-phenylmethyl 2-<<<1-<<(carboxymethyl)thio>methyl>-3-methylbutyl>amino>carbonyl>-4-oxo-1-pyrrolidinecarboxylate 
• 104360-88-5 ((S)-2-{[(S)-1-(4-Methoxy-benzoyl)-pyrrolidine-2-carbonyl]-amino}-4-methyl-pentylsulfanyl)-acetic acid tert-butyl ester 
• 101250-30-0 *,R^*)>-<<2-<<<1-(4-methoxybenzoyl)-2-pyrrolidinyl>carbonyl>amino>-4-methylpentyl>thio>acetate 
• 101250-27-5 *,R^*)>-phenylmethyl 2-<<<1-<<(2-amino-2-oxoethyl)thio>methyl>-3-methylbutyl>amino>carbonyl>-1-pyrrolidinecarboxylate 
• 101250-23-1 <2S-(R^*,R^*)>-phenylmethyl 2-<<<1-<<(carboxymethyl)thio>methyl>-3-methylbutyl>amino>carbonyl>-1-pyrrolidinecarboxylate 
• 101250-67-3 [S-(R*,R*)]-2-[[[1-[[[2-(1,1-Dimethylethoxy)-2-oxoethyl]thio]methyl]-3-methylbutyl]amino]methyl]-1-pyrrolidinecarboxylic acid, phenylmethyl ester 

Relevant academic research and scientific papers

Properties and Reactions of Substituted 1,2-Thiazetidine 1,1-Dioxides: Chiral Mono- and Bicyclic 1,2-Thiazetidine 1,1-Dioxides from α-Amino Acids

New chiral mono- and bicyclic β-sultams, valuable building blocks for drug synthesis, have been prepared from L-Ala, L-Val, L-Leu, L-Ile, L-Phe, L-Cys, L-Ser, L-Thr, and D-penicillamine by transformation of the COOH group into a methylsulfonyl chloride function, followed by cyclization under basic conditions. Selected properties, derivatives, and reactions of the β-sultams are described.

Modified Di- and Tripeptides of the C-Terminal Portion of Oxytocin and Vasopressin as Possible Cognition Activation Agents

A number of peptides and modified peptides were synthesized and studied for their ability to reverse electroconvulsive shock-induced amnesia in rodents.A few of these peptides were selected for secondary evaluation in tests of short-term memory in rats and aged rhesus monkeys.A number of the peptides and modified peptides were active in the amnesia reversal test.In selected secondary tests, however, the chosen compounds failed to show significant activity in enhancing memory.New methods for preparing methyleneamino and methyleneoxy isosters of peptides are reportrd.Other modified peptides also included methylenethio, methylenesulfonyl, and ethylene isosteres in place of the normal peptide amide bond.

Modified tripeptides

Modified oxytocin-vasopressin di- or tri-peptides wherein an amide group is replaced by a group selected from STR1 --CH2 NH--, --CH2 O--, --CH2 S--, --CH2 SO--, --CH2 SO2 --, --CH2/su