882739-48-2 Usage
Uses
Used in Pharmaceutical Industry:
N-(2,2,2-Trichloroethoxysulfonyl)carbonchlorothioic acid S methyl ester is used as a reactant for the preparation of Muramycin analogs, which are potent antibacterial agents effective against drug-resistant bacteria. Its unique reactivity allows for the development of new and more effective treatments for bacterial infections.
Used in Organic Synthesis:
N-(2,2,2-Trichloroethoxysulfonyl)carbonchlorothioic acid S methyl ester is used as a reactant in the preparation of L-epicapreomycidine through a rhodium-catalyzed stereoselective oxidative cyclization process. This method allows for the synthesis of complex organic molecules with high selectivity and efficiency.
Used in Marine Natural Products Synthesis:
N-(2,2,2-Trichloroethoxysulfonyl)carbonchlorothioic acid S methyl ester is used in the synthesis of (+)-gonyautoxin 3 via a rhodium-catalyzed amination process. N-(2,2,2-Trichloroethoxysulfonyl)carbonchlorothioic acid S methyl ester is a key intermediate in the synthesis of more complex members of the marine sponge-derived alkaloid family, such as palau'amine.
Used in the Synthesis of Imidazolidinone and Imino-Imidazolidine Derivatives:
N-(2,2,2-Trichloroethoxysulfonyl)carbonchlorothioic acid S methyl ester is also used in the preparation of 2-imidazolidinones and 2-imino-1,3-imidazolidines, which are important structural motifs in various biologically active compounds. The synthesis of these derivatives can be achieved through a strategy applicable to the preparation of more complex molecules with potential applications in medicine and other fields.
Check Digit Verification of cas no
The CAS Registry Mumber 882739-48-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,2,7,3 and 9 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 882739-48:
(8*8)+(7*8)+(6*2)+(5*7)+(4*3)+(3*9)+(2*4)+(1*8)=222
222 % 10 = 2
So 882739-48-2 is a valid CAS Registry Number.
882739-48-2Relevant academic research and scientific papers
Grelier, Gwendal,Rey-Rodriguez, Romain,Darses, Benjamin,Retailleau, Pascal,Dauban, Philippe
, p. 1880 - 1883 (2017)
The RhII-catalyzed intramolecular C(sp3)–H amination of carbamimidates allowed new nitrogen heterocycles to be isolated in yields up to 99 %. The reaction was best performed in the presence of the Rh2(esp)2 (esp = α,α,α′,α′-tetramethyl-1,3-benzenedipropionic acid) complex by using 2,2,2-trichloroethoxysulfonyl-protected compounds. The reaction could be applied to substrates possessing a benzylic, an allylic, a propargylic, or a tertiary C(sp3)–H bond.
Expanding the substrate scope for C-H amination reactions: Oxidative cyclization of urea and guanidine derivatives
Kim, Mihyong,Mulcahy, John V.,Espino, Christine G.,Du Bois
, p. 1073 - 1076 (2007/10/03)
Oxidative C-H amination of N-trichloroethoxysulfonyl-protected ureas and guanidines is demonstrated to proceed in high yield for tertiary and benzylic-derived substrates. The success of these reactions is predicated on the choice of the electron-withdrawn
