882772-93-2Relevant academic research and scientific papers
Synthesis and antimicrobial activity of azepine and thiepine derivatives
Boinovi, Nina,Novakovi, Irena,Rajai, Sladana Kosti,Opsenica, Igor M.,olaja, Bogdan A.
, p. 839 - 852 (2015/08/24)
A series of new pyridobenzazepine and pyridobenzothiepine derivatives was synthesized by Pd-catalyzed formation of C-N and C-S bonds. All synthesized compounds were tested for their in vitro antimicrobial activity. The pyridobenzazepine derivatives showed better antibacterial and antifungal activity than the corresponding dipyridoazepine analogue. Among the synthesized azepines, derivative 8 displayed potent activity against the tested bacteria (MIC ranged 39-78 μg mL-1), while azepine 12 showed promising antifungal activity (MIC ranged 156-313 μg mL-1). The synthesized thiepine derivatives exhibited weak antibacterial activity, but showed pronounced antifungal activity.
Synthesis and fungicidal activities of novel indene-substituted oxime ether strobilurins
Tu, Song,Xu, Long-He,Ye, Li-Yi,Wang, Xi,Sha, Yong,Xiao, Zong-Yuan
experimental part, p. 5247 - 5253 (2010/04/06)
Nineteen novel indene-substituted oxime ether strobilurins, which used an indene group to stabilize the (E)-styryl group in SYP-Z071 (an unsaturated oxime strobilurin fungicide under development by the Shenyang Research Institute of Chemical Industry), were designed and synthesized. The biological assay results showed that all compounds possessed good or excellent fungicidal activities. It was found that most of the compounds showed higher fungicidal activities against Pyricularia oryzae, Phytophthora infestans, Erysiphe graminis, and Colletotrichum lagenarium than SYP-Z071 at the tested concentration. The biological assay results also indicated that most of the compounds exhibited higher in vivo fungicidal activities against cucumber Pseudoperonospora cubensis and C. lagenarium than the commercial fungicides trifloxystrobin and kresoxim-methyl at a concentration of 6.25 mg/L. Furthermore, it was found that α-(methoxyimino)-N-methylphenylacetamide oxime ethers 6m-s exhibited a broad spectrum and remarkably higher activities against all tested fungi. Especially, the 6-methylindene-substituted compound 6p was identified as the most promising candidate for further study.
