88279-11-2

Basic information

• Product Name: Benzoic acid, 2-azido-5-chloro-
• CAS NO: 88279-11-2
• Molecular Formula: C7H4ClN3O2
• Molecular Weight: 197.581
• Mol File: 88279-11-2.mol

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 2-azido-5-chloro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-azido-5-chloro-(88279-11-2)
• EPA Substance Registry System: Benzoic acid, 2-azido-5-chloro-(88279-11-2)

Safety Data

• Hazardous Substances Data: 88279-11-2(Hazardous Substances Data)

Upstream product

• 635-21-2 5-chloroanthranilic acid 

Downstream Products

• 74873-84-0 2-Azido-5-chlorobenzoyl chloride 
• 944838-61-3 5-chloro-2-(5-chloromethyl-tetrazol-1-yl)-benzoic acid 
• 20324-50-9 5-chloro-2-mercapto-benzoic acid 
• 635-21-2 5-chloroanthranilic acid 
• 830340-94-8 N-(2-azido-5-chlorobenzoyl)-L-proline methyl ester 
• 923975-38-6 C₁₂H₁₁ClN₄O₃ 
• 797751-41-8 1-(2-azido-5-chloro-benzoyl)-azepan-2-one 
• 797751-39-4 1-(2-azido-5-chloro-benzoyl)-piperidin-2-one 
• 797751-37-2 1-(2-azido-5-chloro-benzoyl)-pyrrolidin-2-one 
• 88279-13-4 2-Azido-5-chloro-N-(4-chloro-phenyl)-benzamide 
• 88279-16-7 3,5-dichloro-2-(4-chloro-phenyl)-2H-indazole 

Relevant articles and documents

Continuous flow photolysis of aryl azides: Preparation of 3H-azepinones

Photolysis of aryl azides to give nitrenes, and their subsequent rearrangement in the presence of water to give 3H-azepinones, is performed in continuous flow in a photoreactor constructed of fluorinated ethylene polymer (FEP) tubing. Fine tuning of the reaction conditions using the flow reactor allowed minimization of secondary photochemical reactions.

Catalytic Staudinger/aza-Wittig sequence by in situ phosphane oxide reduction

A Staudinger/aza-Wittig reaction sequence is described that is catalytic in phosphorus. Towards this end, the phosphane oxide is reduced in situ by diphenylsilane, which allows for substoichiometric amounts of the catalyst 5-phenyldibenzophosphole to be used. The substrate scope is investigated and benzoxazoles, benzodiazepine imidates and a 2-methoxypyrrole were successfully synthesized. These investigations show that a fast aza-Wittig reaction is required to obtain high yields. A catalytic Staudinger/aza-Wittig reaction sequence, involving in situ phosphane oxide reduction, was successfully developed. Benzoxazoles, benzodiazepine imidates and 2-methoxypyrrole were synthesized without phosphane oxide waste products. Copyright

USE OF CANNABINOID MODULATING COMPOUNDS IN COMBINATION WITH OTHER THERAPEUTIC COMPOUNDS FOR ADJUNCTIVE THERAPY

The present invention relates to pharmaceutical compositions that contain a compound that modulate the activity of a cannabinoid receptor in conjunction with another therapeutic compound and uses of compounds that modulate the activity of a cannabinoid re

Substituted 1,2,3-triazolo[1,5-a]quinazolines: Synthesis and binding to benzodiazepine and adenosine receptors

This paper reports the synthesis and evaluation of the biological affinity towards benzodiazepine and A1 and A(2A) adenosine receptors of some 3-ethoxycarbonyl or 3-phenyl-substituted 1,2,3-triazolo[I,5-a]quinazolines. Starting from the appropriate chloro-substituted phenylazides, the series of 7 or 8 chloro-substituted triazoloquinazolines were prepared. Nitration reactions of the triazoloquinazoline ring and chlorination reactions of the hydroxyl group in the 5 position of the same ring are also reported. By nucleophilic displacement of halogen, the corresponding 5-amino derivatives and some analogous derivatives bearing cyclohexylamino and p-toluidino substituents were obtained. The binding assays showed a generalized decrease in the affinity towards the benzodiazepine receptors and confirmed a moderate affinity towards the A1 adenosine receptors in comparison with the previously studied triazoloquinazoline derivatives. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

1H- and 2H-Indazoles by Thermal and Photolytic Decomposition of o-Azidobenzoic Acid and o-Azidobenzaldehyde Derivatives

Ethyl o-azidobenzimidate (6) and o-azidobenzamidine (7) on thermolysis yield 3-ethoxy- (9; X=OEt) and 3-amino-1H-indazole (9; X=NH2), respectively.The former product is also obtained on irradiation of the imidate in methanol-tetrahydrofuran solution. 2-Aryl- and 2-heteroaryl-3-chloro-2H-indazoles have been prepared by the action of hot thionyl chloride on o-azidoanilides.The trichloro-2H-indazoles obtained by the action of phosphorus pentachloride on o-azidobenzanilide (12) and by the action of thionyl chloride on N-(o-azidobenzoyl)-2-aminopyridine have been identified as the 3,5,7-trichloro derivatives.The reductive dehalogenation, nitration, and reactivity of the halogen towards nucleophiles, of 3-chloro-2-phenyl-2H-indazole (19) are reported.A new practicable synthesis of o-azidobenzaldehyde (31; X=O) is described.Thermolysis of its phenylhydrazone and semicarbazone derivatives yields 2H-indazoles.