88279-37-2Relevant academic research and scientific papers
Polyhalogenoaromatic Compounds. Part 50. Reactions of 4-Benzyloxytetrahalogenopyridines with Nucleophiles
Julia, Louis,Suschitzky, H.,Barnes, John C.,Tomlin, Clive D.S.
, p. 2507 - 2511 (2007/10/02)
Reaction of 4-benzyloxy-3,5-dichloro-2,6-difluoro- (1; R = CH2Ph) and 4-benzyloxytetrachloropyridine (2; R = CH2Ph) with various nucleophiles (N,N-dimethylhydrazine, piperidine, N,N,N',N'-tetramethylethane-1,2-diamine, triphenylphosphine) occurs unexpectedly at the benzylic methylene group with alkyl-oxygen cleavage to give the corresponding benzylammonium (4) or triphenylphosphonium salt (9) respectively.The molecular structure of the salt derived from 4-benzyloxytetrachloropyridine and N,N-dimethylhydrazine was confirmed by an X-ray study.Preliminary experiments of ut ilising the benzyl cleavage for the preparation of various benzyl derivatives (PhCH2X; X = Cl,Br,I,CN,N3) are described.
