882803-11-4

Usage

Uses

Used in Pharmaceutical Industry:
5-HYDROXY-1H-INDAZOLE-3-CARBOXALDEHYDE is used as a reagent in organic synthesis for the development of new drugs, particularly due to its antioxidant and anti-inflammatory properties. These properties make it a promising candidate for the treatment of various diseases.
Used in Organic Chemistry:
5-HYDROXY-1H-INDAZOLE-3-CARBOXALDEHYDE is used as a precursor for the synthesis of various biologically active compounds and natural products. Its role in the synthesis of heterocyclic compounds further emphasizes its importance in the field of organic chemistry and drug discovery.

Upstream product

• 1953-54-4 indol-5-ol 
• 1346152-69-9 3-formyl-1H-indazol-5-yl acetate 
• 5594-91-2 1H-indol-5-yl acetate 
• 94444-96-9 5-methoxy-1H-indazole 
• 169789-37-1 5-methoxy-1H-indazole-3-carboxaldehyde 
• 169789-36-0 5-methoxy-1H-indazole-3-methanol 
• 90417-53-1 5-methoxy-1H-indazole-3-carboxylic acid 

Relevant academic research and scientific papers

ANTICANCER AGENT

An anticancer agent comprising a compound represented by the formula (I) [R1 represents hydrogen atom, hydroxyl group, a C1-6alkoxy group and the like; R2 and R3 represents hydrogen atom, a halogen atom, a C1-6alkyl group and the like; R4 represents hydrogen atom, a C1-6alkyl group, a C1-6alkylsulfonyl group and the like; R5 represents hydrogen atom or a substituent; .... represents a single bond or a double bond; R6 and R7 represents hydrogen atom, a C1-6alkyl group and the like; R8 represents hydrogen atom, a C1-6alkyl group and the like; A represents -O-, -S-, or - CH2-; D represents -C= or -N=; X represents methylene group, -O-, or -CO-; Q represents -N= or -C(R8)=; and Y represents a heterocyclic group or amino group], which shows a superior inhibitory activity against pim-1 kinase.

The serotonin 5-HT4 receptor. 2. Structure-activity studies of the indole carbazimidamide class of agonists.

A number of substituted indole carbazimidamides were prepared and evaluated as 5-HT4 receptor agonists by using the isolated field-stimulated guinea pig ileum preparation. Their selectivity for the 5-HT4 receptor was established by examining their affinity for other 5-HT receptors using radioligand-binding techniques. Several selective and highly potent full as well as partial agonists emerged from this study. For example, 1b,d were found to be the most potent, full 5-HT4 receptor agonist described so far (EC50 = 0.5 and 0.8 nM, respectively), being 6 and 4 times more potent than serotonin itself. On the other hand, 5b and 1h appeared as partial 5-HT4 receptor agonists in the nonstimulated guinea pig ileum preparation with potencies, evaluated against serotonin action, respectively similar (5b, Ki = 12 nM) to and 300-fold higher (1h, Ki = 0.04 nM) than serotonin.