88283-10-7Relevant academic research and scientific papers
Synthesis in water and antimicrobial activity of 5-trichloromethyl-4,5- dihydroisoxazoles
Flores, Alex F. C.,Piovesan, Luciana A.,Souto, Alynne A.,Pereira, Mariano A.,Martins, Marcos A. P.,Balliano, Tatiane L.,Da Silva, Givanildo S.
supporting information, p. 2326 - 2336 (2013/07/26)
Two series of 5-trichloromethylisoxazoles were synthesized from the cyclocondensation of 1,1,1-trichloro-4-methoxy-3-alken-2-ones [Cl 3CC(O)C(R2) = C(R1)O Me, where R1 = H, Me, Et, Pr, iso-Pr, cyclo-Pr, Bu, terc
A convenient one-pot synthesis of 5-carboxyisoxazoles: Trichloromethyl group as a carboxyl group precursor
Martins, Marcos A. P.,Flores, Alex F. C.,Bastos, Giovani P.,Sinhorin, Adilson,Bonacorso, Helio G.,Zanatta, Nilo
, p. 293 - 297 (2007/10/03)
The one-pot synthesis of ten 5-carboxyisoxazoles from the cyclocondensation of β-alkoxyvinyl trichloromethyl ketones [CCl3C(O)C(R2)=C(R1)OR, where R1, R2=H, Me and R=Me, Et] and 2- trichloroacetyl cyclohexanone with hydroxylamine is reported. This work shows that the trichloromethyl group attached to β-alkoxyvinyl trichloromethyl ketones (a heterocyclic CCC building block) is an excellent carboxyl group precursor.
