88287-80-3

Upstream product

• 88287-77-8 3-(2,3,5-Tri-O-benzyl-β-D-ribofuranosyl)-4-aminopyrazole-5-carbonitrile 
• 31083-47-3 Methyl 3-(2,3,5-tri-O-benzyl-β-D-ribofuranosyl)-5-carbamoylpyrazole-4-carboxylate 
• 88295-39-0 3-(2,3,5-Tri-O-benzyl-β-D-ribofuranosyl)-4-<<(2,2,2-trichloroethoxy)carbonyl>amino>pyrazole-5-carbonitrile 
• 88287-72-3 3-(2,3,5-Tri-O-benzyl-β-D-ribofuranosyl)-5-cyanopyrazole-4-carboxylic acid 
• 88287-69-8 Methyl 3-(2,3,5-Tri-O-benzyl-β-D-ribofuranosyl)-5-cyanopyrazole-4-carboxylate 

Downstream Products

• 88287-84-7 4-(3-Benzoyl-2-benzyl-isothioureido)-5-((2S,3S,4R,5R)-3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-2H-pyrazole-3-carbothioic acid amide 
• 88287-86-9 3-(2,3,5-Tri-O-benzyl-β-D-ribofuranosyl)-5-(benzylthio)-7-aminopyrazolo<4,3-d>pyrimidine 
• 88287-85-8 N-[3-((2S,3S,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-7-thioxo-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-benzamide 
• 80523-94-0 3-(2,3,5-Tri-O-benzyl-β-D-ribofuranosyl)-5-aminopyrazolo<4,3-d>pyrimidine-7-thione 

Relevant academic research and scientific papers

Synthesis of 3-Glycofuranosyl-5-aminopyrazolopyrimidine-7-thiones: Thioguanosine-Type C-Nucleosides

The first C-nucleosides of the thioguanosine type are the 3-β-D-ribofuranosyl, 3-β-D-arabinofuranosyl, and 3-(2-deoxy-β-D-erythro-pentofuranosyl)derivatives of 5-aminopyrazolopyrimidine-7-thione.Synthesis of these products employed C6H5CH2SC(Cl)=NCOC6H5 as a new reagent for ring closure of the 3-glycofuranosyl-4-aminopyrazole-5-carbothiamide precursors.The new ring closure requires fewer steps and minimizes side reactions encountered in previous guanosine ring closure.The amino thioamide precursors are prepared from pyrazole C-nucleosides available as in previous formycin syntheses.