882876-36-0

Upstream product

• 882745-53-1 1-(4-methylphenyl)-1-methyl-3-methylenecyclohexane 
• 94853-56-2 3-methyl-3-(4-methylphenyl)-pent-4-enal 
• 6330-12-7 3-(4-methylphenyl)cyclohex-2-enone 
• 5720-05-8 4-methylphenylboronic acid 
• 30182-67-3 1,3-Cyclohexanedione 
• 23074-59-1 3-isobutoxycyclohex-2-en-1-one 
• 1193-18-6 3-methylcyclohexen-2-one 
• 4294-57-9 para-methylphenylmagnesium bromide 
• 92862-87-8 (rac)-3-(4-methylphenyl)-3-methylcyclohexanone 
• 882745-48-4 6-methyl-6-p-tolyl-octa-1,7-dien-4-ol 
• 882745-49-5 5-methyl-5-p-tolyl-cyclohex-3-enol 
• 882745-50-8 5-(4-methylphenyl)-5-methylcyclohex-3-enone 

Relevant academic research and scientific papers

Catalytic enantioselective total synthesis of (?)-ar-Tenuifolene

First catalytic asymmetric total synthesis of aromatic sesquiterpene, (?)-ar-teunifolene (1) is featured (3 steps, 75% overall yields) from commercially available 3-methyl cyclohex-2-enone 16. The enantioenriched 3,3-disubstituted cyclohexanone 11 is obtained from Pd(II)-catalyzed enantioselective (p-tolyl)boronic acid addition to 3-methyl cyclohex-2-enone 16 in 90% ee, which is found to be the key intermediate. A diastereoselective methyllithium addition of this enantioenriched product followed by dehydration completes straightforward access to (?)-ar-teunifolene (1).

First synthesis of (±)-tenuifolene and ar-tenuifolene

First total synthesis of the sesquiterpenes (±)-tenuifolene and (±)-ar-tenuifolene, isolated from the essential oil of the East African sandalwood tree Osyris tenuifolia, has been accomplished.