883000-78-0Relevant academic research and scientific papers
A general approach to indole-7-yl derivatives of isoxazole, oxadiazole, thiadiazole and pyrazole
Polozov, Alexandre M.,Hategan, Georgeta,Cao, Hua,Kiselyov, Alex S.,Zeller, Wayne,Singh, Jasbir
experimental part, p. 575 - 578 (2010/04/02)
Isosteric replacement of the α,β-unsaturated amide at the C-7 position of indoles with a diverse set of five-membered amino-heterocycles including isoxazole, oxadiazole, thiadiazole and pyrazole followed by subsequent derivatization of the heterocyclic amino group to yield amides, sulfonamides and phosphoramides is described. Distinctive features of these procedures include the versatility and robust nature of the synthetic steps along with the high yields of the targeted molecules.
PROCESS FOR PREPARING 7-(ACRYLOYL)INDOLES
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Page/Page column 10, (2008/06/13)
The present invention involves a process for preparing substituted indoles, such as DTSI involving two sequential cross-coupling reactions.
7-(ACRYLOYL) INDOLE COMPOSITIONS AND METHODS FOR MAKING AND USING SAME
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Page/Page column 21-22, (2010/11/29)
The present invention is directed to pharmaceutical compositions of 7-(acryloyl) indoles, such as 4,5-Dichloro-thiophene-2-sulfonic acid [(E)-3-[1-(2,4-dichlorophenylmethyl)-5-fluoro-3-methyl-1H-indol-7-yl]-acryloyl]amide (DTSI). The invention is also dir
ARYL SULFONAMIDE PERI-SUBSTITUTED BICYCLICS FOR OCCLUSIVE ARTERY DISEASE
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Page/Page column 60, (2008/06/13)
Aryl sulfonamide, peri-substituted, fused bicyclic ring compounds useful for the treatment or prophylaxis of a prostaglandin-mediated disease or condition are disclosed. The compounds are of the general formula (I). A representative example is formula (II
