883000-80-4

Upstream product

• 67-56-1 methanol 
• 883000-78-0 7-bromo-1-(2,4-dichlorobenzyl)-5-fluoro-3-methyl-1H-indole 
• 883000-79-1 1-(2,4-Dichloro-benzyl)-5-fluoro-3-methyl-1H-indole-7-carboxylic acid ethyl ester 

Downstream Products

• 1208065-24-0 1-(2,4-dichloro-benzyl)-5-fluoro-3-methyl-1H-indole-7-carboxylic acid iminomethyleneamide 
• 1208065-22-8 C₁₈H₁₃Cl₂FN₄S 

Relevant academic research and scientific papers

A general approach to indole-7-yl derivatives of isoxazole, oxadiazole, thiadiazole and pyrazole

Isosteric replacement of the α,β-unsaturated amide at the C-7 position of indoles with a diverse set of five-membered amino-heterocycles including isoxazole, oxadiazole, thiadiazole and pyrazole followed by subsequent derivatization of the heterocyclic amino group to yield amides, sulfonamides and phosphoramides is described. Distinctive features of these procedures include the versatility and robust nature of the synthetic steps along with the high yields of the targeted molecules.

ARYL SULFONAMIDE PERI-SUBSTITUTED BICYCLICS FOR OCCLUSIVE ARTERY DISEASE

Aryl sulfonamide, peri-substituted, fused bicyclic ring compounds useful for the treatment or prophylaxis of a prostaglandin-mediated disease or condition are disclosed. The compounds are of the general formula (I). A representative example is formula (II