883019-45-2

Upstream product

• 883019-31-6 4-(4-fluorophenyl)-1-(3,4-dimethoxyphenylacetyl)thiosemicarbazide 
• 1544-68-9 4-fluorophenyl isothiocyanate 
• 60075-23-2 3,4-dimethoxyphenylacetic acid hydrazide 

Downstream Products

• 1239956-61-6 3-(2,6-difluorobenzylthio)-5-(3,4-dimethoxybenzyl)-4-(4-fluorophenyl)-4H-1,2,4-triazole 

Relevant academic research and scientific papers

TRIAZOLE AND IMIDAZOLE DERIVATIVES FOR USE AS TGR5 AGONISTS IN THE TREATMENT OF DIABETES AND OBESITY

The present invention comprises TGR5 agonists of structural formula I, wherein X, R1, R2, and R5 are defined herein, as well as N-oxides of them and pharmaceutically acceptable salts thereof. The invention further comprise

Synthesis, lipophilicity and antimicrobial activity of new derivatives of thiosemicarbazides and 1,2,4-triazoline-5-thione

In the reaction of hydrazide of 3,4-dimethoxyphenylacetic acid (1) with isothiocyanate the respective thiosemicarbazide derivatives (2) were obtained. Further cyclization with 2% NaOH led to the formation of 3- [(3,4- dimethoxyphenyl)methyl]-4-substituted-1,2,4-triazoline-5-thiones (3). The structures of all new products were confirmed by analytical and spectroscopic methods. All compounds were screened for their in vitro activity against some species of aerobic bacteria and fungi. The lipophilicity of the synthesized molecules was also studied.