5-(3,4-DIMETHOXY-BENZYL)-4-(4-FLUORO-PHENYL)-4H-[1,2,4]TRIAZOLE-3-THIOL

Base Information

• Chemical Name: 5-(3,4-DIMETHOXY-BENZYL)-4-(4-FLUORO-PHENYL)-4H-[1,2,4]TRIAZOLE-3-THIOL
• CAS No.: 883019-45-2
• Molecular Formula: C₁₇H₁₆FN₃O₂S
• Molecular Weight: 345.397
• Mol file: 883019-45-2.mol

Synonyms:5-(3,4-dimethoxybenzyl)-4-(4-fluorophenyl)-4H-1,2,4-triazole-3-thiol

Chemical Property of 5-(3,4-DIMETHOXY-BENZYL)-4-(4-FLUORO-PHENYL)-4H-[1,2,4]TRIAZOLE-3-THIOL

Chemical Property:

Purity/Quality:

5-(3,4-Dimethoxybenzyl)-4-(4-fluorophenyl)-4H-1,2,4-triazole-3-thiol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(3,4-DIMETHOXY-BENZYL)-4-(4-FLUORO-PHENYL)-4H-[1,2,4]TRIAZOLE-3-THIOL

There total 4 articles about 5-(3,4-DIMETHOXY-BENZYL)-4-(4-FLUORO-PHENYL)-4H-[1,2,4]TRIAZOLE-3-THIOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4-(4-fluorophenyl)-1-(3,4-dimethoxyphenylacetyl)thiosemicarbazide (883019-31-6) → 4-(4-fluorophenyl)-3-(3,4-dimethoxyphenylmethyl)-1,2,4-triazoline-5-thione (883019-45-2)

Guidance literature:

With sodium hydroxide; In water; for 2h; Reflux;

Reference yield: 81.0%

4-(4-fluorophenyl)-1-(3,4-dimethoxyphenylacetyl)thiosemicarbazide (883019-31-6) → 5-(3,4-dimethoxybenzyl)-4-(4-fluorophenyl)-4H-1,2,4-triazole-3-thiol (883019-45-2)

Guidance literature:

4-(4-fluorophenyl)-1-(3,4-dimethoxyphenylacetyl)thiosemicarbazide; With sodium hydroxide; for 3h; Reflux;

With hydrogenchloride; In water; pH=5; Cooling;

Reference yield:

3,4-dimethoxyphenylacetic acid hydrazide (60075-23-2) → 5-(3,4-dimethoxybenzyl)-4-(4-fluorophenyl)-4H-1,2,4-triazole-3-thiol (883019-45-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ethanol / Reflux

2.1: sodium hydroxide / 3 h / Reflux

2.2: pH 5 / Cooling

With sodium hydroxide; In ethanol;

upstream raw materials:

4-(4-fluorophenyl)-1-(3,4-dimethoxyphenylacetyl)thiosemicarbazide

3,4-dimethoxyphenylacetic acid hydrazide

4-fluorophenyl isothiocyanate

Downstream raw materials:

3-(2,6-difluorobenzylthio)-5-(3,4-dimethoxybenzyl)-4-(4-fluorophenyl)-4H-1,2,4-triazole