883046-91-1Relevant academic research and scientific papers
Synthesis, spectral studies and antimicrobial activities of some 2-naphthyl pyrazoline derivatives
Sakthinathan,Vanangamudi,Thirunarayanan
experimental part, p. 693 - 700 (2012/07/17)
A series of 2-naphthyl pyrazolines were synthesized by the cyclization of 2-naphthyl chalcones and phenylhydrazine hydrochloride in the presence of sodium acetate. The yields of pyrazoline derivatives are more than 80%. The synthesized pyrazolines were characterized by their physical constants, IR, 1H, 13C and MS spectra. From the IR and NMR spectra the CN (cm-1) stretches, the pyrazoline ring proton chemical shifts (ppm) of δHa, Hb and Hc and also the carbon chemical shifts (ppm) of δCN are correlated with Hammett substituent constants, F and R, and Swain-Lupton's parameters using single and multi-regression analyses. From the results of linear regression analysis, the effect of substituents on the group frequencies has been predicted. The antimicrobial activities of all synthesized pyrazolines have been studied.
