883107-06-0Relevant academic research and scientific papers
Novel bifunctional quinolonyl diketo acid derivatives as HIV-1 integrase inhibitors: Design, synthesis, biological activities, and mechanism of action
Di Santo, Roberto,Costi, Roberta,Roux, Alessandra,Artico, Marino,Lavecchia, Antonio,Marinelli, Luciana,Novellino, Ettore,Palmisano, Lucia,Andreotti, Mauro,Amici, Roberta,Galluzzo, Clementina Maria,Nencioni, Lucia,Palamara, Anna Teresa,Pommier, Yves,Marchand, Christophe
, p. 1939 - 1945 (2007/10/03)
The virally encoded integrase protein is an essential enzyme in the life cycle of the HIV-1 virus and represents an attractive and validated target in the development of therapeutics against HIV infection. Drugs that selectively inhibit this enzyme, when
