883141-49-9Relevant articles and documents
Interfering with HuR-RNA Interaction: Design, Synthesis and Biological Characterization of Tanshinone Mimics as Novel, Effective HuR Inhibitors
Manzoni, Leonardo,Zucal, Chiara,Maio, Danilo Di,D'Agostino, Vito G.,Thongon, Natthakan,Bonomo, Isabelle,Lal, Preet,Miceli, Marco,Baj, Vanessa,Brambilla, Marta,Cerofolini, Linda,Elezgarai, Saioa,Biasini, Emiliano,Luchinat, Claudio,Novellino, Ettore,Fragai, Marco,Marinelli, Luciana,Provenzani, Alessandro,Seneci, Pierfausto
, p. 1483 - 1498 (2018/03/05)
The human antigen R (HuR) is an RNA-binding protein known to modulate the expression of target mRNA coding for proteins involved in inflammation, tumorigenesis, and stress responses and is a valuable drug target. We previously found that dihydrotanshinone
A concise synthesis of novel naphtho[a]carbazoles and benzo[c]carbazoles
Pathak, Rakhi,Nhlapo, Johanna M.,Govender, Sameshnee,Michael, Joseph P.,Van Otterlo, Willem A. L.,De Koning, Charles B.
, p. 2820 - 2830 (2007/10/03)
Starting from simple indole precursors the synthesis of naphtho[a]carbazoles and benzo[c]carbazoles is described. Key steps include the use of the Suzuki-Miyaura reaction to afford 2- or 3-aryl substituted indoles, as well as a potassium t-butoxide and light assisted aromatic ring-forming reaction.
