883194-84-1

Basic information

• Product Name: 1H-Imidazole, 1-[(1-methyl-1H-imidazol-4-yl)carbonyl]-
• CAS NO: 883194-84-1
• Molecular Formula: C8H8N4O
• Molecular Weight: 176.178
• Mol File: 883194-84-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1H-Imidazole, 1-[(1-methyl-1H-imidazol-4-yl)carbonyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Imidazole, 1-[(1-methyl-1H-imidazol-4-yl)carbonyl]-(883194-84-1)
• EPA Substance Registry System: 1H-Imidazole, 1-[(1-methyl-1H-imidazol-4-yl)carbonyl]-(883194-84-1)

Safety Data

• Hazardous Substances Data: 883194-84-1(Hazardous Substances Data)

Upstream product

• 530-62-1 1,1'-carbonyldiimidazole 
• 41716-18-1 1-methylimidazole-4-carboxylic acid 

Relevant articles and documents

Synthesis and evaluation of human phosphodiesterases (PDE) 5 inhibitor analogs as trypanosomal PDE inhibitors. Part 1. Sildenafil analogs

Parasitic diseases, such as African sleeping sickness, have a significant impact on the health and well-being in the poorest regions of the world. Pragmatic drug discovery efforts are needed to find new therapeutic agents. In this Letter we describe target repurposing efforts focused on trypanosomal phosphodiesterases. We outline the synthesis and biological evaluation of analogs of sildenafil (1), a human PDE5 inhibitor, for activities against trypanosomal PDEB1 (TbrPDEB1). We find that, while low potency analogs can be prepared, this chemical class is a sub-optimal starting point for further development of TbrPDE inhibitors.