88323-95-9Relevant academic research and scientific papers
Synthesis of 3-Hydroxy-2-(substituted thiazolyl)-4-thiazolidinones
Mane, R. A.,Ingle, D. B.
, p. 690 - 692 (2007/10/02)
5-Acetyl-2-alkyl/alkylamino-4-methylthiazoles (IIa) and 5-acetyl-4-methyl-2-(substituted sulphamylphenylamino)thiazoles (IIb) have been synthesized by the interaction of 3-chloroacetylacetone with thioamides/alkylthiocarbamides (Ia) and substituted sulphamylphenylthiocarbamides (Ib), respectively.The acetyl derivatives (IIa-c) on treatment with hydroxylamine hydrochloride in pyridine yield the oxamino derivatives (III), which undergo condensation with thioglycolic acid (IV) in the presence of orthophosphoric acid in dry tetrahydrofuran to furnish the title compounds (V).
